prikaz prve stranice dokumenta The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484
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The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484
Open Biology, 7 (2017); 11. https://doi.org/10.1098/rsob.170153
Bradshaw, Nicholas J.; Ukkola-Vuoti, Liisa; Pankakoski, Maiju; Zheutlin, Amanda B.; Ortega-Alonso, Alfredo; Torniainen-Holm, Minna; Sinha, Vishal; Therman, Sebastien; Paunio, Tiina; Suvisaari, Jaana; Lönnqvist, Jouko; Cannon, Tyrone D.; Haukka, Jari; Hennah, William

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Bradshaw, N. J., Ukkola Vuoti, L., Pankakoski, M., Zheutlin, A. B., Ortega Alonso, A., Torniainen Holm, M. ... Hennah, W. (2017). The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484. Open Biology, 7.. doi: 10.1098/rsob.170153

Bradshaw, Nicholas J., et al. "The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484." Open Biology, vol. 7, 2017. https://doi.org/10.1098/rsob.170153

Bradshaw, Nicholas J., Liisa Ukkola Vuoti, Maiju Pankakoski, Amanda B. Zheutlin, Alfredo Ortega Alonso, Minna Torniainen Holm, Vishal Sinha, et al. "The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484." Open Biology 7 (2017). https://doi.org/10.1098/rsob.170153

Bradshaw, N. J., et al. (2017) 'The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484', Open Biology, 7. doi: 10.1098/rsob.170153

Bradshaw NJ, Ukkola Vuoti L, Pankakoski M, Zheutlin AB, Ortega Alonso A, Torniainen Holm M, i sur.. The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484. Open Biology [Internet]. 15.11.2017. [pristupljeno 19.11.2024.];7. doi: 10.1098/rsob.170153

N. J. Bradshaw, et al., "The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484", Open Biology, vol. 7, Studeni 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:397281. [Citirano: 19.11.2024.]

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Naslov (engleski)The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484
AutorNicholas J. Bradshaw
AutorLiisa Ukkola-Vuoti
AutorMaiju Pankakoski
AutorAmanda B. Zheutlin
AutorAlfredo Ortega-Alonso
AutorMinna Torniainen-Holm
AutorVishal Sinha
AutorSebastien Therman
AutorTiina Paunio
AutorJaana Suvisaari
AutorJouko Lönnqvist
AutorTyrone D. Cannon
AutorJari Haukka
AutorWilliam Hennah
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Biologija
Sažetak (engleski)
Genetic studies of familial schizophrenia in Finland have observed significant associations with a group of biologically related genes, DISC1, NDE1, NDEL1, PDE4B and PDE4D, the ‘DISC1 network’. Here, we use gene expression and psychoactive medication use data to study their biological consequences and potential treatment implications. Gene expression levels were determined in 64 individuals from 18 families, while prescription medication information has been collected over a 10-year period for 931 affected individuals. We demonstrate that the NDE1 SNP rs2242549 associates with significant changes in gene expression for 2908 probes (2542 genes), of which 794 probes (719 genes) were replicable. A significant number of the genes altered were predicted targets of microRNA-484 (p = 3.0 x10-8), located on a non-coding exon of NDE1. Variants within the NDE1 locus also displayed significant genotype by gender interaction to early cessation of psychoactive medications metabolized by CYP2C19. Furthermore, we demonstrate that miR-484 can affect the expression of CYP2C19 in a cell culture system. Thus, variation at the NDE1 locus may alter risk of mental illness, in part through modification of miR-484, and such modification alters treatment response to specific psychoactive medications, leading to the potential for use of this locus in targeting treatment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaOpen Biology
Brojčani podacivol. 7, 11
e-ISSN2046-2441
DOIhttps://doi.org/10.1098/rsob.170153
URN:NBNurn:nbn:hr:193:397281
Datum objave publikacije2017-11-15
URL dokumentahttp://rsob.royalsocietypublishing.org/content/7/11/170153
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2018-09-14 11:00:25