prikaz prve stranice dokumenta The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484
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Scientific paper - Original scientific paper
The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484
Open Biology, 7 (2017); 11. https://doi.org/10.1098/rsob.170153
Bradshaw, Nicholas J.; Ukkola-Vuoti, Liisa; Pankakoski, Maiju; Zheutlin, Amanda B.; Ortega-Alonso, Alfredo; Torniainen-Holm, Minna; Sinha, Vishal; Therman, Sebastien; Paunio, Tiina; Suvisaari, Jaana; Lönnqvist, Jouko; Cannon, Tyrone D.; Haukka, Jari; Hennah, William

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Bradshaw, N. J., Ukkola Vuoti, L., Pankakoski, M., Zheutlin, A. B., Ortega Alonso, A., Torniainen Holm, M. ... Hennah, W. (2017). The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484. Open Biology, 7.. doi: 10.1098/rsob.170153

Bradshaw, Nicholas J., et al. "The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484." Open Biology, vol. 7, 2017. https://doi.org/10.1098/rsob.170153

Bradshaw, Nicholas J., Liisa Ukkola Vuoti, Maiju Pankakoski, Amanda B. Zheutlin, Alfredo Ortega Alonso, Minna Torniainen Holm, Vishal Sinha, et al. "The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484." Open Biology 7 (2017). https://doi.org/10.1098/rsob.170153

Bradshaw, N. J., et al. (2017) 'The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484', Open Biology, 7. doi: 10.1098/rsob.170153

Bradshaw NJ, Ukkola Vuoti L, Pankakoski M, Zheutlin AB, Ortega Alonso A, Torniainen Holm M, and sur.. The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484. Open Biology [Internet]. 2017 November 15 [cited 2024 November 27];7. doi: 10.1098/rsob.170153

N. J. Bradshaw, et al., "The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484", Open Biology, vol. 7, November 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:397281. [Accessed: 27 November 2024]

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Metadata
Title (english)The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484
AuthorNicholas J. Bradshaw
AuthorLiisa Ukkola-Vuoti
AuthorMaiju Pankakoski
AuthorAmanda B. Zheutlin
AuthorAlfredo Ortega-Alonso
AuthorMinna Torniainen-Holm
AuthorVishal Sinha
AuthorSebastien Therman
AuthorTiina Paunio
AuthorJaana Suvisaari
AuthorJouko Lönnqvist
AuthorTyrone D. Cannon
AuthorJari Haukka
AuthorWilliam Hennah
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Biology
Abstract (english)
Genetic studies of familial schizophrenia in Finland have observed significant associations with a group of biologically related genes, DISC1, NDE1, NDEL1, PDE4B and PDE4D, the ‘DISC1 network’. Here, we use gene expression and psychoactive medication use data to study their biological consequences and potential treatment implications. Gene expression levels were determined in 64 individuals from 18 families, while prescription medication information has been collected over a 10-year period for 931 affected individuals. We demonstrate that the NDE1 SNP rs2242549 associates with significant changes in gene expression for 2908 probes (2542 genes), of which 794 probes (719 genes) were replicable. A significant number of the genes altered were predicted targets of microRNA-484 (p = 3.0 x10-8), located on a non-coding exon of NDE1. Variants within the NDE1 locus also displayed significant genotype by gender interaction to early cessation of psychoactive medications metabolized by CYP2C19. Furthermore, we demonstrate that miR-484 can affect the expression of CYP2C19 in a cell culture system. Thus, variation at the NDE1 locus may alter risk of mental illness, in part through modification of miR-484, and such modification alters treatment response to specific psychoactive medications, leading to the potential for use of this locus in targeting treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleOpen Biology
Numberingvol. 7, 11
e-ISSN2046-2441
DOIhttps://doi.org/10.1098/rsob.170153
URN:NBNurn:nbn:hr:193:397281
Publication2017-11-15
Document URLhttp://rsob.royalsocietypublishing.org/content/7/11/170153
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2018-09-14 11:00:25