prikaz prve stranice dokumenta Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids
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Scientific paper - Original scientific paper
Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids
International Journal of Molecular Sciences, 24 (2023), 11; 9333. https://doi.org/10.3390/ijms24119333
Tseilikman, Vadim E.; Fedotova, Julia O.; Tseilikman, Olga B.; Novak, Jurica; Karpenko, Marina N.; Maistrenko, Victoria A.; Lazuko, Svetlana S.; Belyeva, Lyudmila E.; Kamel, Mustapha; Buhler, Alexey V.; Kovaleva, Elena G.

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Tseilikman, V. E., Fedotova, J. O., Tseilikman, O. B., Novak, J., Karpenko, M. N., Maistrenko, V. A. ... Kovaleva, E. G. (2023). Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. International Journal of Molecular Sciences, 24. (11). doi: 10.3390/ijms24119333

Tseilikman, Vadim E., et al. "Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids." International Journal of Molecular Sciences, vol. 24, no. 11, 2023. https://doi.org/10.3390/ijms24119333

Tseilikman, Vadim E., Julia O. Fedotova, Olga B. Tseilikman, Jurica Novak, Marina N. Karpenko, Victoria A. Maistrenko, Svetlana S. Lazuko, et al. "Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids." International Journal of Molecular Sciences 24, no. 11 (2023). https://doi.org/10.3390/ijms24119333

Tseilikman, V. E., et al. (2023) 'Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids', International Journal of Molecular Sciences, 24(11). doi: 10.3390/ijms24119333

Tseilikman VE, Fedotova JO, Tseilikman OB, Novak J, Karpenko MN, Maistrenko VA, and sur.. Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. International Journal of Molecular Sciences [Internet]. 2023 May 26 [cited 2024 November 16];24(11). doi: 10.3390/ijms24119333

V. E. Tseilikman, et al., "Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids", International Journal of Molecular Sciences, vol. 24, no. 11, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:225850. [Accessed: 16 November 2024]

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Metadata
Title (english)Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids
AuthorVadim E. Tseilikman
AuthorJulia O. Fedotova https://orcid.org/0000-0002-3117-9299
AuthorOlga B. Tseilikman
AuthorJurica Novak
AuthorMarina N. Karpenko
AuthorVictoria A. Maistrenko https://orcid.org/0000-0001-7004-7873
AuthorSvetlana S. Lazuko
AuthorLyudmila E. Belyeva
AuthorMustapha Kamel
AuthorAlexey V. Buhler
AuthorElena G. Kovaleva
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Abstract (english)
Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic CYP3A activity. Trans-resveratrol, a natural polyphenol, has been extensively studied for its antipsychiatric properties. Recently, protective effects of trans-resveratrol were found in relation to PTSD. Treatment of PTSD rats with trans-resveratrol allowed the rats to be divided into two phenotypes. The first phenotype is treatment-sensitive rats (TSR), and the second phenotype is treatment-resistant rats (TRRs). In TSR rats, trans-resveratrol ameliorated anxiety-like behavior and reversed plasma corticosterone concentration abnormalities. In contrast, in TRR rats, trans-resveratrol aggravated anxiety-like behavior and decreased plasma corticosterone concentration. In TSR rats, hepatic 11β-HSD-1 activity was suppressed, with a concomitant increase in CYP3A activity. In TRR rats, the activities of both enzymes were suppressed. Thus, the resistance of PTSD rats to trans-resveratrol treatment is associated with abnormalities in hepatic metabolism of glucocorticoids. The free energy of binding of resveratrol, cortisol, and corticosterone to the human CYP3A protein was determined using the molecular mechanics Poisson–Boltzmann surface area approach, indicating that resveratrol could affect CYP3A activity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 11, 9333
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24119333
URN:NBNurn:nbn:hr:193:225850
Publication2023-05-26
Document URLhttp://bib.irb.hr/1275834
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-31 11:21:54