prikaz prve stranice dokumenta Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids
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Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids
International Journal of Molecular Sciences, 24 (2023), 11; 9333. https://doi.org/10.3390/ijms24119333
Tseilikman, Vadim E.; Fedotova, Julia O.; Tseilikman, Olga B.; Novak, Jurica; Karpenko, Marina N.; Maistrenko, Victoria A.; Lazuko, Svetlana S.; Belyeva, Lyudmila E.; Kamel, Mustapha; Buhler, Alexey V.; Kovaleva, Elena G.

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Tseilikman, V. E., Fedotova, J. O., Tseilikman, O. B., Novak, J., Karpenko, M. N., Maistrenko, V. A. ... Kovaleva, E. G. (2023). Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. International Journal of Molecular Sciences, 24. (11). doi: 10.3390/ijms24119333

Tseilikman, Vadim E., et al. "Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids." International Journal of Molecular Sciences, vol. 24, br. 11, 2023. https://doi.org/10.3390/ijms24119333

Tseilikman, Vadim E., Julia O. Fedotova, Olga B. Tseilikman, Jurica Novak, Marina N. Karpenko, Victoria A. Maistrenko, Svetlana S. Lazuko, et al. "Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids." International Journal of Molecular Sciences 24, br. 11 (2023). https://doi.org/10.3390/ijms24119333

Tseilikman, V. E., et al. (2023) 'Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids', International Journal of Molecular Sciences, 24(11). doi: 10.3390/ijms24119333

Tseilikman VE, Fedotova JO, Tseilikman OB, Novak J, Karpenko MN, Maistrenko VA, i sur.. Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. International Journal of Molecular Sciences [Internet]. 26.05.2023. [pristupljeno 19.01.2025.];24(11). doi: 10.3390/ijms24119333

V. E. Tseilikman, et al., "Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids", International Journal of Molecular Sciences, vol. 24, br. 11, Svibanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:225850. [Citirano: 19.01.2025.]

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Podaci o radu
Naslov (engleski)Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids
AutorVadim E. Tseilikman
AutorJulia O. Fedotova https://orcid.org/0000-0002-3117-9299
AutorOlga B. Tseilikman
AutorJurica Novak
AutorMarina N. Karpenko
AutorVictoria A. Maistrenko https://orcid.org/0000-0001-7004-7873
AutorSvetlana S. Lazuko
AutorLyudmila E. Belyeva
AutorMustapha Kamel
AutorAlexey V. Buhler
AutorElena G. Kovaleva
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Sažetak (engleski)
Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic CYP3A activity. Trans-resveratrol, a natural polyphenol, has been extensively studied for its antipsychiatric properties. Recently, protective effects of trans-resveratrol were found in relation to PTSD. Treatment of PTSD rats with trans-resveratrol allowed the rats to be divided into two phenotypes. The first phenotype is treatment-sensitive rats (TSR), and the second phenotype is treatment-resistant rats (TRRs). In TSR rats, trans-resveratrol ameliorated anxiety-like behavior and reversed plasma corticosterone concentration abnormalities. In contrast, in TRR rats, trans-resveratrol aggravated anxiety-like behavior and decreased plasma corticosterone concentration. In TSR rats, hepatic 11β-HSD-1 activity was suppressed, with a concomitant increase in CYP3A activity. In TRR rats, the activities of both enzymes were suppressed. Thus, the resistance of PTSD rats to trans-resveratrol treatment is associated with abnormalities in hepatic metabolism of glucocorticoids. The free energy of binding of resveratrol, cortisol, and corticosterone to the human CYP3A protein was determined using the molecular mechanics Poisson–Boltzmann surface area approach, indicating that resveratrol could affect CYP3A activity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 11, 9333
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24119333
URN:NBNurn:nbn:hr:193:225850
Datum objave publikacije2023-05-26
URL dokumentahttp://bib.irb.hr/1275834
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-05-31 11:21:54