prikaz prve stranice dokumenta The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS
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Scientific paper - Review paper
The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS
International Journal of Molecular Sciences, 23 (2022), 19; 1-18. https://doi.org/10.3390/ijms231911360
Glavač, Damjan; Mladinić, Miranda; Ban, Jelena; Mazzone, Graciela L; Sámano, Cynthia; Tomljanović, Ivana; Jezernik, Gregor; Ravnik-Glavač, Metka

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Glavač, D., Mladinić, M., Ban, J., Mazzone, G. L., Sámano, C., Tomljanović, I. ... Ravnik Glavač, M. (2022). The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS. International Journal of Molecular Sciences, 23. (19), 1-18. doi: 10.3390/ijms231911360

Glavač, Damjan, et al. "The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS." International Journal of Molecular Sciences, vol. 23, no. 19, 2022, pp. 1-18. https://doi.org/10.3390/ijms231911360

Glavač, Damjan, Miranda Mladinić, Jelena Ban, Graciela L Mazzone, Cynthia Sámano, Ivana Tomljanović, Gregor Jezernik and Metka Ravnik Glavač. "The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS." International Journal of Molecular Sciences 23, no. 19 (2022): 1-18. https://doi.org/10.3390/ijms231911360

Glavač, D., et al. (2022) 'The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS', International Journal of Molecular Sciences, 23(19), pp. 1-18. doi: 10.3390/ijms231911360

Glavač D, Mladinić M, Ban J, Mazzone GL, Sámano C, Tomljanović I, and sur.. The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS. International Journal of Molecular Sciences [Internet]. 2022 September 26 [cited 2024 November 19];23(19):1-18. doi: 10.3390/ijms231911360

D. Glavač, et al., "The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS", International Journal of Molecular Sciences, vol. 23, no. 19, pp. 1-18, September 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:689981. [Accessed: 19 November 2024]

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Metadata
Title (english)The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS
AuthorDamjan Glavač
AuthorMiranda Mladinić
AuthorJelena Ban
AuthorGraciela L Mazzone
AuthorCynthia Sámano
AuthorIvana Tomljanović
AuthorGregor Jezernik
AuthorMetka Ravnik-Glavač
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Abstract (english)
Neurodegenerative diseases are one of the greatest medical burdens of the modern age, being mostly incurable and with limited prognostic and diagnostic tools. Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by the loss of motoneurons, with a complex etiology, combining genetic, epigenetic, and environmental causes. The neuroprotective therapeutic approaches are very limited, while the diagnostics rely on clinical examination and the exclusion of other diseases. The recent advancement in the discovery of molecular pathways and gene mutations involved in ALS has deepened the understanding of the disease pathology and opened the possibility for new treatments and diagnostic procedures. Recently, 15 risk loci with distinct genetic architectures and neuron-specific biology were identified as linked to ALS through common and rare variant association analyses. Interestingly, the quantity of related proteins to these genes has been found to change during early postnatal development in mammalian spinal cord tissue (opossum Monodelphis domestica) at the particular time when neuroregeneration stops being possible. Here, we discuss the possibility that the ALS-related genes/proteins could be connected to neuroregeneration and development. Moreover, since the regulation of gene expression in developmental checkpoints is frequently regulated by non-coding RNAs, we propose that studying the changes in the composition and quantity of non-coding RNA molecules, both in ALS patients and in the developing central nervous (CNS) system of the opossum at the time when neuroregeneration ceases, could reveal potential biomarkers useful in ALS prognosis and diagnosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 19, pp. 1-18
p-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms231911360
URN:NBNurn:nbn:hr:193:689981
Publication2022-09-26
ProjectNumber: IP-2016-06-7060
Title (croatian): Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca
Acronym: DefineREgenAgeMode
Leader: Miranda Mladinić Pejatović
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/1422-0067/23/19/11360
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-05 16:32:37