prikaz prve stranice dokumenta The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS
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The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS
International Journal of Molecular Sciences, 23 (2022), 19; 1-18. https://doi.org/10.3390/ijms231911360
Glavač, Damjan; Mladinić, Miranda; Ban, Jelena; Mazzone, Graciela L; Sámano, Cynthia; Tomljanović, Ivana; Jezernik, Gregor; Ravnik-Glavač, Metka

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Glavač, D., Mladinić, M., Ban, J., Mazzone, G. L., Sámano, C., Tomljanović, I. ... Ravnik Glavač, M. (2022). The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS. International Journal of Molecular Sciences, 23. (19), 1-18. doi: 10.3390/ijms231911360

Glavač, Damjan, et al. "The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS." International Journal of Molecular Sciences, vol. 23, br. 19, 2022, str. 1-18. https://doi.org/10.3390/ijms231911360

Glavač, Damjan, Miranda Mladinić, Jelena Ban, Graciela L Mazzone, Cynthia Sámano, Ivana Tomljanović, Gregor Jezernik i Metka Ravnik Glavač. "The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS." International Journal of Molecular Sciences 23, br. 19 (2022): 1-18. https://doi.org/10.3390/ijms231911360

Glavač, D., et al. (2022) 'The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS', International Journal of Molecular Sciences, 23(19), str. 1-18. doi: 10.3390/ijms231911360

Glavač D, Mladinić M, Ban J, Mazzone GL, Sámano C, Tomljanović I, i sur.. The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS. International Journal of Molecular Sciences [Internet]. 26.09.2022. [pristupljeno 08.12.2024.];23(19):1-18. doi: 10.3390/ijms231911360

D. Glavač, et al., "The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS", International Journal of Molecular Sciences, vol. 23, br. 19, str. 1-18, Rujan 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:689981. [Citirano: 08.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:193:689981
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Podaci o radu
Naslov (engleski)The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS
AutorDamjan Glavač
AutorMiranda Mladinić
AutorJelena Ban
AutorGraciela L Mazzone
AutorCynthia Sámano
AutorIvana Tomljanović
AutorGregor Jezernik
AutorMetka Ravnik-Glavač
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Sažetak (engleski)
Neurodegenerative diseases are one of the greatest medical burdens of the modern age, being mostly incurable and with limited prognostic and diagnostic tools. Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by the loss of motoneurons, with a complex etiology, combining genetic, epigenetic, and environmental causes. The neuroprotective therapeutic approaches are very limited, while the diagnostics rely on clinical examination and the exclusion of other diseases. The recent advancement in the discovery of molecular pathways and gene mutations involved in ALS has deepened the understanding of the disease pathology and opened the possibility for new treatments and diagnostic procedures. Recently, 15 risk loci with distinct genetic architectures and neuron-specific biology were identified as linked to ALS through common and rare variant association analyses. Interestingly, the quantity of related proteins to these genes has been found to change during early postnatal development in mammalian spinal cord tissue (opossum Monodelphis domestica) at the particular time when neuroregeneration stops being possible. Here, we discuss the possibility that the ALS-related genes/proteins could be connected to neuroregeneration and development. Moreover, since the regulation of gene expression in developmental checkpoints is frequently regulated by non-coding RNAs, we propose that studying the changes in the composition and quantity of non-coding RNA molecules, both in ALS patients and in the developing central nervous (CNS) system of the opossum at the time when neuroregeneration ceases, could reveal potential biomarkers useful in ALS prognosis and diagnosis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 19, str. 1-18
p-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms231911360
URN:NBNurn:nbn:hr:193:689981
Datum objave publikacije2022-09-26
ProjektŠifra: IP-2016-06-7060
Naziv (hrvatski): Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca
Kratica: DefineREgenAgeMode
Voditelj: Miranda Mladinić Pejatović
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/1422-0067/23/19/11360
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-10-05 16:32:37