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master's thesis
Istraživanje derivata vitamina B6 jednodimenzijskim i dvodimenzijskim tehnikama NMR
2018. urn:nbn:hr:193:331876
Busić, Dajana
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Busić, D. (2018). Istraživanje derivata vitamina B6 jednodimenzijskim i dvodimenzijskim tehnikama NMR (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:331876

Busić, Dajana. "Istraživanje derivata vitamina B6 jednodimenzijskim i dvodimenzijskim tehnikama NMR." Master's thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:331876

Busić, Dajana. "Istraživanje derivata vitamina B6 jednodimenzijskim i dvodimenzijskim tehnikama NMR." Master's thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:331876

Busić, D. (2018). 'Istraživanje derivata vitamina B6 jednodimenzijskim i dvodimenzijskim tehnikama NMR', Master's thesis, University of Rijeka, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:193:331876

Busić D. Istraživanje derivata vitamina B6 jednodimenzijskim i dvodimenzijskim tehnikama NMR [Master's thesis]. Rijeka: University of Rijeka; 2018 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:193:331876

D. Busić, "Istraživanje derivata vitamina B6 jednodimenzijskim i dvodimenzijskim tehnikama NMR", Master's thesis, University of Rijeka, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:193:331876

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Metadata
TitleIstraživanje derivata vitamina B6 jednodimenzijskim i dvodimenzijskim tehnikama NMR
Title (english)Investigation of vitamin B6 derivatives by one- and two-dimensional NMR techniques
AuthorDajana Busić
MentorDražen Vikić-Topić (mentor)
MentorSunčica Roca (mentor)
Committee memberDean Marković (predsjednik povjerenstva)
Committee memberKarlo Wittine (član povjerenstva)
Committee memberDražen Vikić-Topić (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2018-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U sklopu ovog istraživanja sintetizirani su novi spojevi derivata vitamina B6 i to piridoksina s aminokiselinama (alanin i fenilalanin), te neutralnog piridoksala s primarnim aminom (2-amin-4-klorfenol) u molarnom omjeru 1 : 1. Amino skupina alanina zaštićena je s tert-butiloksikarbonilnom skupinom (Boc), a fenilalanina s karboksibenzil zaštitnom skupinom (Z). Oba aminokiselinska estera dobivena su reakcijom aminokiselina s dicikloheksilkarbodiimidom (DCC) i α4,α5-izobutiliden piridoksinom. Schiffova baza prethodno neutraliziranog piridoksal hidroklorida dobivena je njegovom reakcijom s 2-amin-4-klorfenolom. Dobiveni spojevi okarakterizirani su 1D i 2D spektroskopijom NMR u otopini, spektrometrijom masa (ESI-MS) te spektroskopijom IR zračenja u čvrstom stanju. Od 1D tehnika NMR korištene su 1H i 13C APT, a od 2D 1H—1H COSY, 1H—1H NOESY, 1H—13C HMQC, 1H—13C HMBC i 1H—15N HMBC.
Abstract (english)
Three compounds of vitamine B6 derivatives were prepared by reaction of pyridoxine with amino acids (alanine and phenylalanine), and by reaction of neutral pyridoxal and primary amine (2-amino-4-chlorophenol). As N(alpha)-amino protecting group, tert-butoxycarbonyl (Boc-Ala) and carboxybenzyl group (Z-Phe) were used. Both aminoacids esters were prepared by reaction of aminoacids with N,N'-dicyclohexylcarbodiimide (DCC) and α4,α5- isobutylidene pyridoxine. Schiff's base was synthesized by reaction of neutral pyridoxal and 2-amino-4-chlorophenol. All synthesized compounds were identified by NMR spectroscopy in solution and mass spectrometry. Used one-dimensional NMR techniques were 1H and 13C APT, while the two-dimensional used techniques were 1H—1H COSY, 1H—1H NOESY, 1H—13C HMQC, 1H—13C HMBC and 1H—15N HMBC. In solid state the compounds were characterized by IR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:331876
Study programmeTitle: Medicinal chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-10-31 08:14:45