prikaz prve stranice dokumenta Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi
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master's thesis
Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi
2018. urn:nbn:hr:193:980378
Bracanović, Sara
University of Rijeka
Faculty of Biotechnology and Drug Development

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Bracanović, S. (2018). Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:980378

Bracanović, Sara. "Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi." Master's thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:980378

Bracanović, Sara. "Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi." Master's thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:980378

Bracanović, S. (2018). 'Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi', Master's thesis, University of Rijeka, accessed 29 October 2024, https://urn.nsk.hr/urn:nbn:hr:193:980378

Bracanović S. Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi [Master's thesis]. Rijeka: University of Rijeka; 2018 [cited 2024 October 29] Available at: https://urn.nsk.hr/urn:nbn:hr:193:980378

S. Bracanović, "Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi", Master's thesis, University of Rijeka, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:193:980378

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TitleSinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi
Title (english)Synthesis of 4H-thieno[3,2-c]chromen-4-one derivatives and evaluation of their anti-inflammatory activity on pSTAT1 and pSTAT5 isolated from peripheral blood mononuclear cells
AuthorSara Bracanović
MentorKarlo Wittine (mentor)
Committee memberDean Marković (predsjednik povjerenstva)
Committee memberSandra Kraljević Pavelić (član povjerenstva)
Committee memberKarlo Wittine (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2018-12-10, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
ovom radu opisana je sinteza tricikličkih angularnih spojeva, 4H-tieno[3,2-c]kromen-4-ona (7-8, 9a-e) i derivata (5-(2-hidroksi-4-metoksifenil) tiofen-2,4-di-il)dimetanola (5, 6a-d). Ispitana je protuupalna učinkovitost spojeva 4, 7, 8 i 9a-e in vitro, mjerenjem učinkovitosti inhibicije različitih fosfo-STAT proteina (engl. Signal Transducer and Activatior of Transcription) koji su dio JAK (engl. Janus kinase)/STAT signalnog puta. Spoj 7 (etil 7-hidroksi-4-okso-4H-tieno[3,2-c]kromen-2-karboksilat) pokazao je najbolja inhibicijska svojstva sa vrijednostima IC50 5,0 μM (pSTAT5/GM-CSF/PBMC); IC50 49,5 μM (pSTAT5/IL-2/PBMC) i IC50 10,50 μM (pSTAT1/IFN-/PBMC).
Abstract (english)
Synthesis of tricyclic angular compounds, namely 4H-thieno[3,2-c]chromen-4-one (7-8, 9a-e) and (5-(2-hydroxy-4-methoxyphenyl) thiophene-2,4-diyl)dimethanol (5, 6a-d) derivatives, is described. Compounds 4, 7, 8 and 9a-e were tested in vitro for their anti-inflammatory activity, by measuring various pSTAT (signal transducer and activator of transcription) inhibition within the JAK (Janus-activated family kinase)/STAT signaling pathway. Compound 7 (ethyl 7-hydroxy-4-oxo-4H-thieno[3,2-c]chromene-2-carboxylate) showed best inhibition properties on inhibition of pSTAT5 in GM-CSF-triggered assay, with IC50 value of 5.0 μM. Inhibition of pSTAT5 in IL-2-triggered assay showed IC50 value of 49.5 μM, while inhibition of pSTAT1 in IFN--triggered assay showed IC50 value of 10.5 μM.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:980378
Study programmeTitle: Medicinal chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2020-01-01
Terms of useLicence In copyright icon
Created on2018-12-20 08:48:32