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Design strategies for SARS-CoV-2 spike protein mimetics based on peptide self-assembly
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Katarina Budić Supramolecular chemistry is a discipline that studies the characteristics
of non-covalent bonds between molecules and / or ions. Advances in
supramolecular chemistry in the last two decades have enabled the fabrication
and design of peptide nanostructures. Peptides are biological molecules whose
sequences are naturally self-assembled in water and organized into
nanostructures. They are often investigated as carriers in targeted drug
delivery, and their purpose has been found in...
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Detekcija i kvantifikacija metabolita pesticida u Eisenia Fetida tekućinskom kromatografijom ultra visoke djelotvornosti
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Mateo Rabak Pesticidi su prirodne ili sintetske molekule napravljene za očuvanje usjeva, hrane i zaštite od bolesti koje prenose nametnici. Veliki problem je nakupljanje pesticida u životinjama, biljkama i ljudima koje dovodi do zagađenja okoliša te šteti ljudskom zdravlju. Diamidni insekticid klorantraniliprol i triazolni fungicid propikonazol pesticidi su kojim se bavi ovaj rad.
U ovom radu opisana je standardizirana metoda za detekciju i kvantifikaciju metaboliziranih pesticida iz gujavica...
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Development and validation of LC-MS/MS method for N-nitrosamines analysis in pharmaceutical products
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Ivan Grgičević N-nitrosamines are a class of organic compounds with a chemical structure that contains a nitroso (-NO) functional group attached to the amine nitrogen. Such an amine can have one or two alkyl groups attached to the nitrogen atom. According to various studies, most nitrosamines have been confirmed to be carcinogenic in various animal studies but potentially also in humans. For example, a higher incidence of gastric and oesophageal cancer has been described in people who were more exposed to...
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Development of Dual Reporter Luciferase system for in vivo detection of miRNA target gene downregulation
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Kristina Žuža Most frequent global death causes are cardiovascular disorders such as cerebrovascular diseases, high blood pressure, congenital heart disease and coronary artery disease. Cardiovascular diseases often result in development of heart failure syndrome which in most cases leads to death within 5 years after diagnosis. Similar to heart failure, acute myocardial infarction is a silent murderer of today’s developed society due to sedentary life style and unhealthy habits such as smoking and...
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Development of a yeast model system for interrogating the influence of beta-oxidation on mitochondrial cardiolipin turnover
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Ana Maria Ivanov Barth syndrome is a multi-system genetic disorder that affects the
mitochondria. It is characterized by a wide range of conditions mostly affecting
the heart and skeletal muscles. Symptoms include: cardiomyopathy, skeletal
myopathy, neutropenia, increased urinary excretion of 3-methylglutaconic
acid and weaker motor skills. What causes the disorder is the mutations in the
tafazzin (TAZ) gene, which codes the tafazzin enzyme that, in healthy cells, is
widely present in cardiac and...
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Diferencijacija stanica neuroblastoma kao model u istraživanju latentne infekcije herpes simpleks virusa
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Katja Badanjak U neuroznanosti i virologiji Herpes simpleks virusa tipa 1 postoji težnja ka idealnom in vitro modelnom sustavu u istraživanjima koja se bave proučavanjem latentne infekcije HSV-1 virusa. Mnoge studije su se usredotočile na diferencijaciju stanica neuroblastoma u stanice nalik neuronima. Diferencijacijom pomoću retinoične kiseline i neurotrofnog faktora BDNF mogu se dobiti stanice promijenjene morfologije i biokemije. Homogena kultura takvih diferenciranih stanica rutinski se koristi u...
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Differentiation of acute and chronic exposure to METH on fAGEs accumulation and behavioral phenotypes
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Ana Klasan Methamphetamine (METH) and cocaine (COC) are often used recreational
drugs that target dopaminergic synaptic transmission. Repeated exposure
to a specific drug that causes increased motor-stimulant response is termed
behavioral sensitization. In D. melanogaster, behavioral sensitization can
be measured and induced with METH and COC. Dopamine has a role in
changes included in neural plasticity after drug intake, such as behavioral
sensitization. Furthermore, it determines various...
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Diimidna redukcija i redukcija tri- i tetrapiridilporfirina s kositar(II) kloridom
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Barbara Rojnić Fotodinamička terapija (PDT) je jedan od suvremenijih pristupa u liječenju tumora te je još uvijek u razvoju. Za PDT su potrebne tri komponente: fotosenzibilizator (PS), izvor svjetlosti i molekularni kisik. Uspješnost PDT-a ovisi o svojstvima PS-a, a trenutno su najčešće korišteni tetrapirolni makrocikli: porfirini, klorini i bakterioklorini. Klorini i bakterioklorini imaju jači apsorpcijski pik u crvenom području (~ 650 - 750 nm) od porfirina (~ 630 nm) te ih upravo to fizikalno...
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Dijagnostički, prognostički i terapijski značaj profiliranja N-glikoma kod kolorektalnog karcinoma
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Patricia Plantak Kolorektalni karcinom (CRC, engl. colorectal cancer) nastaje kada stanice u debelom crijevu ili rektumu izgube svoju sposobnost kontrole diobe i preživljavanja nakon čega dolazi do njihovog abnormalnog rasta. S otprilike 1,8 milijuna novih slučajeva u 2018., CRC je treći najčešći karcinom u muškaraca i drugi u žena te drugi najsmrtonosniji karcinom u svijetu. Povećana razina CEA ili CA19-9 u serumu ukazuje na prisutnost CRC-a. Međutim, mjerenje njihovih razina kao test za CRC...
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Dinamika ekspresije molekula važnih za aktivaciju imunološkog sustava u stanicama visceralnog masnog tkiva u debljini
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Anamaria Đukić Šećerna bolest tipa 2 (engl. Type 2 Diabetes Mellitus, T2D) je kronična metabolička bolest koja se razvija kao kombinacija rezistencije perifernih tkiva na hormon inzulin i neučinkovitog odgovora β-stanica Langerhansovih otočića gušterače. Očituje se kao stanje kronične hiperglikemije s poremećenim metabolizmom ugljikohidrata, bjelančevina i masti.
Pretilost je jedan od ključnih rizičnih čimbenika za razvoj inzulinske rezistencije (engl. Insulin Resistance, IR) i T2D. Masno...
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