Pages
-
-
Cell-type specific glycosylation patterns of mouse CD63 detected by newly produced mouse monoclonal antibodies
-
Nina Žarković CD63 is an evolutionary conserved transmembrane glycoprotein which is ubiquitously expressed in mammalian cells and abundantly located in late endosomes and lysosomes. It has no enzymatic activity, but exerts its functions by interacting with other proteins to act on a wide range of cellular processes like cytoskeletal organisation, cell adhesion and motility. At least some of these CD63 functions might explain the association of CD63 with cancer metastasis seen in clinical settings....
-
-
Cellular parabiosis
-
Lucija Miseta Since the human lifespan has been extended in the past decades, age-related diseases have become a significant societal problem. Thus, life science research is increasingly attempting to develop approaches to delay or attenuate aging and age-related diseases. These attempts target mostly cell-autonomous factors. However, it has been shown that during aging cell populations become increasingly heterogenous, with some cells still young and functional and others damaged or dying. This has...
-
-
Characterization of antibodies specific for MCMV proteins MCK-2 and gO
-
Josipa Jerak Cytomegalovirus (CMV) is β-herpesvirus, which establishes lifelong latent infection in host. CMV is transmitted through bodily fluids and represents the most frequent congenital infection in humans. Infection of healthy individuals with human CMV (HCMV) is usually asymptomatic, however, it can cause severe disease in immunocompromised individuals, as well as in infants infected in the prenatal period. CMV has broad tropism, infecting majority of cell types and organs. Viral glycoproteins...
-
-
Chemoresistance in colon cancer: focus on conventional chemotherapy
-
Klara Mladenić Colorectal cancer (CRC) is a widespread tumour type amongst men and women. Despite the available screening tests, this disease is most likely to be discovered when already having progressed to an advanced stage that is palliatively treated with conventional or cytotoxic chemotherapeutics. The latter typically involves 5-fluorouracil (5-FU), oxaliplatin (Ox) and irinotecan (CPT-11), first-line therapeutics that stumble upon chemoresistance in the majority of cases of metastatic or advanced...
-
-
Cikloadicijske reakcije porfirina za dobivanje klorina i bakterioklorina
-
Ida Šimunčić Porfirini, prirodni heterociklički spojevi, u pericikličkim reakcijama mogu sudjelovati kao dieni, dienofili, dipolarofili te 1,3-dipoli kako bi se sintetizirali novi, potencijalno biološki aktivni derivati - klorini i bakterioklorini. Osim što pokazuju optička i fotokemijska svojstva, navedeni spojevi karakteristični su po svojoj stereospecifičnosti te endo i egzo selektivnosti reakcija kojim se dobivaju. Za sintezu novih porfirina mogu se koristiti različite pericikličke reakcije:...
-
-
Cistična fibroza: patofiziologija i terapijski pristupi
-
Marko Lušić Cistična fibroza multisistemska je autosomno recesivna genetska bolest. Unutar zadnjih nekoliko godina napravljeni su veliki koraci u razumijevanju patofiziologije cistične fibroze, što je omogućilo pretpostavku mehanizma koji uzrokuje kliničku sliku pacijenata. Otkriće CFTR (engl. cystic fibrosis transmembrane conductance regulator) gena 1989. godine, omogućilo je pretpostavku strukture i funkcije CFTR proteina. Nakon toga otkrića opisano je više od 2000 varijanti CFTR gena te...
-
-
Citotoksično djelovanje kapara (Capparis spinosa L.) na različite stanične linije humanih karcinoma
-
Ivana Gabela Karcinomi su skup različitih bolesti koje se međusobno razlikuju prema svojoj etiologiji, biologiji i kliničkoj slici te posljedično i po načinu liječenja. Progresivno povećanje nekontrolirane stanične diobe razlog je što se karcinom klinički najčešće očituje kao nakupina velikog broja zloćudno preobraženih stanica. Karcinom je drugi vodeći uzrok smrti u svijetu, a odgovoran je za 9,6 milijuna smrtnih slučajeva u 2018. godini. Karcinom mokraćnog mjehura je deveti...
-
-
Classification and identification of central nervous system glia
-
Marta Pongrac Glia is a very heterogeneous cell population comprised of very different cells that work together to maintain central nervous system (CNS) homeostasis. Long believed role of glia being the acellular connective tissue has been overturned, and they have become focus of intense research. Due to the technological advances, new functions are being discovered, as well as interactions of glia with neurons and the glia between themselves. During CNS development, radial glia guide neuronal migration,...
-
-
Comparison of different FYVE domains and anti-PI3P antibody for monitoring the localization of PI3P in BALB 3T3 cells
-
Tea Bruketa Phosphoinositides are phosphorylated membrane lipids that control the intracellular membrane traffic and have a role in cell signaling. Phosphatidylinositol 3-phosphate (PI3P) is a key regulator of membrane and vesicular trafficking localized primarily on the early and late endosomal membranes where it regulates endosomal maturation. The major source of PI3P is the class III phosphoinositide 3-kinase vacuolar protein sorting 34 (Vps34). In the cells, PI3P can be visualized using antibodies...
Pages
