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Citirajte ovaj rad
Novak, J. (2023). CYP3A4 [Skup podataka]. https://urn.nsk.hr/urn:nbn:hr:193:361490.
Novak, Jurica. CYP3A4. Odjel za biotehnologiju, 2023. 24.08.2024. https://urn.nsk.hr/urn:nbn:hr:193:361490.
Novak, Jurica. 2023. CYP3A4. Odjel za biotehnologiju. https://urn.nsk.hr/urn:nbn:hr:193:361490.
Novak, J. 2023. CYP3A4. Odjel za biotehnologiju. [Online]. [Citirano 24.08.2024.]. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:193:361490.
Novak J. CYP3A4. [Internet]. Odjel za biotehnologiju: Rijeka, HR; 2023, [pristupljeno 24.08.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:361490.
J. Novak, CYP3A4, Odjel za biotehnologiju, 2023. Citirano: 24.08.2024. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:361490.
Jurica Novak Odjel za biotehnologiju, Sveučilište u Rijeci
Suradnik
Vadim E. Tseilikman (Researcher) Južnouralsko Državno Sveučilište, Čeljabinsk, Rusija
Znanstveno / umjetničko područje, polje i grana
PRIRODNE ZNANOSTI Kemija Teorijska kemija
Sažetak (engleski)
Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic CYP3A activity. Trans-resveratrol, a natural polyphenol, has been extensively studied for its antipsychiatric properties. Recently, protective effects of trans-resveratrol were found in relation to PTSD. Treatment of PTSD rats with trans-resveratrol allowed the rats to be divided into two phenotypes. The first phenotype is treatment-sensitive rats (TSR), and the second phenotype is treatment-resistant rats (TRR). In TSR rats, trans-resveratrol ameliorated anxiety-like behavior and reversed plasma corticosterone concen-tration abnormalities. In contrast, in TRR rats, trans-resveratrol aggravated anxiety-like behav-ior and decreased plasma corticosterone concentration. In TSR rats, hepatic 11β-HSD-1 activity was suppressed, with a concomitant increase in CYP3A activity. In TRR rats, the activities of both enzymes were suppressed. Thus, the resistance of PTSD rats to trans-resveratrol treatment is as-sociated with abnormalities in hepatic metabolism of glucocorticoids. The free energy of bind-ing of resveratrol, cortisol, and corticosterone to the human CYP3A protein was determined us-ing the molecular mechanics Poisson-Boltzmann surface area approach, indicating that resvera-trol could affect CYP3A activity.