Raman spectroscopy method for the identification of a small organic molecule was developed and validated in accordance with the guidelines of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use ICH Q2 (R1). The criteria were defined as a part of the development and validation of Raman method for identification of substances Benzoyl peroxide, hydrous and Clindamycin hydrochloride to prove the reliability and suitability of the use of Raman spectroscopy. The acceptance criteria of the proposed identification method were examined through the selectivity parameter that tests the specificity and robustness of the Raman method for identifying the substance. Acceptance criteria were defined for positive and negative test according to the manufacturer's instructions Thermo Scientific for TruScan RM Analyzer. p-value results each of the analysed samples (Benzoyl peroxide, hydrous and Clindamycin hydrochloride) in Positive test was higher than 0.1 and passed the acceptance criteria (p≥0.1). Methods created for the above-mentioned samples correctly confirmed the type of the raw material. Negative test (database selectivity test) confirmed that the created method correctly distinguishes tested substances from other raw materials with a similar chemical structure. Introduction and validation procedure determined the suitability of the proposed Raman spectroscopy method for Benzoyl peroxide, hydrous and Clindamycin hydrochloride identification.