New controlled drug delivery systems are being developed to improve the therapeutic efficacy of drugs and to keep under control existing side effects. Two tripeptide gelators were synthesized 1. organogelator Z-L-Phe-L-Phe-LAlaNH2 and 2. hydrogelator Ac-L-Phe-L-Phe-L-AlaNH2 with the aim of studying their potential to develop drug depot systems and controlled release systems of nonsteroidal antireumatics (NSAR). After long-term oral administration of NSAR, such as ibuprofen and acetylsalicylic acid, serious side effects may occur in the gastrointestinal tract. Transdermal controlled drug delivery by gels represents an alternative method of drug administration by which unwanted effects are avoided. For the liquid component of organogel a soybean oil was selected, and phosphate buffer was selected for the hydrogel liquid component. Ibuprofen and acetylsalicylic acid were loaded in the tripeptide gels and the release behavior of drugs in phosphate buffer was investigated by using UV-Vis spectroscopy. Further, the influence of the pH values of the accepting media on the release behavior of ibuprofen from organogel was investigated. Release behavior was measured by two different systems. Cumulative, taking the sample through a certain period of time and determining drug concentration using UV Vis spectroscopy (in cuvette cell) or directly using optic probe. The results obtained by different measurement methods were compared. The hydrogelator potential during the mechanochemical reaction of hydrogelator and ibuprofen in the mill was studied in order to improve the solubility of the hydrophobic drug in aqueous solution. The results indicated that studied gelators are very good media for drug depot systems. pH of the accepting media has a major impact on the release behavior of ibuprofen molecules. Alkaline media is more suitable for release. The UV-Vis spectrophotometric probe is suitable for real-time drug delivery monitoring but due to saturation of the accepting buffer, high release rates are not achieved. Cumulative method, by transferring the half volume of the accepting media (0.1M phosphate buffer, pH 7.4) to a cuvette and adding equal amounts of a new solution of the accepting media, the saturation of the accepting solution is not achieved and higher release rates are obtained. By mechanochemical mixing of hydrogelator and lipophilic drug, it is possible to introduce a lipophilic drug into the aqueous phase and facilitate self assembly in the hydrogel.