prikaz prve stranice dokumenta Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma
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Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma
Acta Haematologica, 136 (2016), 1; 52-61. https://doi.org/10.1159/000444624
Duletić-Načinović, Antica; Gačić, Vedrana; Valković, Toni; Lučin, Ksenija; Fišić, Elizabeta; Žuvić-Butorac, Marta; Seili-Bekafigo, Irena; Jonjić, Nives

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Duletić Načinović, A., Gačić, V., Valković, T., Lučin, K., Fišić, E., Žuvić Butorac, M. ... Jonjić, N. (2016). Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma. Acta Haematologica, 136. (1), 52-61. doi: 10.1159/000444624

Duletić Načinović, Antica, et al. "Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma." Acta Haematologica, vol. 136, br. 1, 2016, str. 52-61. https://doi.org/10.1159/000444624

Duletić Načinović, Antica, Vedrana Gačić, Toni Valković, Ksenija Lučin, Elizabeta Fišić, Marta Žuvić Butorac, Irena Seili Bekafigo i Nives Jonjić. "Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma." Acta Haematologica 136, br. 1 (2016): 52-61. https://doi.org/10.1159/000444624

Duletić Načinović, A., et al. (2016) 'Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma', Acta Haematologica, 136(1), str. 52-61. doi: 10.1159/000444624

Duletić Načinović A, Gačić V, Valković T, Lučin K, Fišić E, Žuvić Butorac M, i sur.. Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma. Acta Haematologica [Internet]. 10.05.2016. [pristupljeno 17.11.2024.];136(1):52-61. doi: 10.1159/000444624

A. Duletić Načinović, et al., "Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma", Acta Haematologica, vol. 136, br. 1, str. 52-61, Svibanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:136705. [Citirano: 17.11.2024.]

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Naslov (engleski)Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma
AutorAntica Duletić-Načinović
AutorVedrana Gačić
AutorToni Valković
AutorKsenija Lučin
AutorElizabeta Fišić
AutorMarta Žuvić-Butorac
AutorIrena Seili-Bekafigo
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Sažetak (engleski)
Background: Diffuse large B-cell lymphomas (DLBCL) are heterogeneous diseases, and the identification of additional DLBCL risk factors is especially important. Methods: In this pilot study, we determined pretreatment serum levels of vascular endothelial growth factor (VEGF), osteopontin (OPN) and macrophage chemotactic protein-1 (MCP-1) in 67 newly diagnosed DLBCL patients before treatment with standard chemoimmunotherapy and in 30 healthy persons. Results: Serum levels of all three cytokines were significantly elevated in untreated patients compared to controls. VEGF and OPN concentrations were higher in patients with advanced Ann Arbor stage, B symptoms, Eastern Cooperative Oncology Group score ≥2, International Prognostic Index (IPI) ≥3 and partial/no remission. A high MCP-1 level was associated with advanced stage, increased IPI and bone marrow infiltration. In univariate analysis, elevated OPN and VEGF, and concurrent elevation of all three biomarkers, were identified as significant predictors of poor survival. Multivariate Cox analysis revealed that elevated OPN combined with elevated VEGF levels was one of the best parameter subsets predicting poorest survival. Conclusion: According to our preliminary results, serum levels of VEGF and OPN before treatment predict response to therapy and survival after chemoimmunotherapy, and may help to further stratify DLBCL patients into risk groups.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeRadna verzija
Naslov časopisaActa Haematologica
Brojčani podacivol. 136, br. 1, str. 52-61
p-ISSN0001-5792
e-ISSN1421-9662
DOIhttps://doi.org/10.1159/000444624
URN:NBNurn:nbn:hr:193:136705
Datum objave elektroničkog izdanja2016-05-10
URL dokumentahttps://www.karger.com/Article/Abstract/444624
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-09-30 10:02:45