Psoriasis is a chronic inflammatory skin disease, characterised by abnormal proliferation of keratinocytes in the upper layer of the skin. It is a multigenic and immune-mediated disease that involves complex interactions between the innate and adaptive immune systems, in which the IL-23/Th17 axis plays a major role. Genetic factors combined with environmental factors such as obesity, stress, smoking and infections also contribute to the development and worsening of the disease. There are several types of psoriasis, but the most common type is plaque psoriasis, characterised by reddish plaques accompanied by silvery-white scales. The diagnosis of psoriasis is based on the clinical picture and family history of the disease, but in rare cases, a biopsy can also be performed. The Psoriasis Area and Severity Index (PASI) and the Dermatological Quality of Life Index (DQLI) are used to assess the severity of the disease and its impact on the patient's quality of life. These criteria are also used for monitoring the progress of the disease and adjusting the therapy according to the needs of the patients. Treatment of psoriasis varies depending on the severity of the disease. Mild forms of the disease are treated with topical therapies and phototherapy, while more severe forms are treated with biological agents that have shown great progress in the treatment of psoriasis. Although existing therapies are effective, they cause several side effects, which is why there is a constant need to develop new and improved treatment methods. Future approaches include the development of biomarkers and the application of Multi-Omics technology for better understanding and monitoring of the disease. Drug delivery innovations such as microneedles and topical nanocarriers are also being introduced. Psoriasis has a significant impact on the quality of life of patients and is associated with comorbidities such as depression, psoriatic arthritis and cardiovascular diseases, which require a holistic and multidisciplinary approach to the treatment of patients and new more effective treatments.