Paginacija
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The role of B cells in the pathogenesis and therapy of multiple sclerosis
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Katarina Bulić Multiple sclerosis (MS) is an autoimmune disorder that targets myelin sheaths in the central nervous system. It is a chronic disorder and although the axonal damage is initially reversible, at later stages it eventually results in neuroaxonal loss. It has a wide range of symptoms including sensory, autonomic nervous system, motoric and cognitive problems. It affects over 2.5 million people in the world, and starts in most patients at 20 to 40 years of age. MS is a multifactorial disease,...
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The role of DTNBP1/dysbindin-1 in schizophrenia
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Ema Belužić Schizophrenia is complex neurological disease that is present in 1% of the general population. It is known as a multifactorial disease because of the simultaneous influence of genetic and environmental factors. Some of the symptoms that are recognized are hallucinations, delusions, loss of energy and motivation and cognitive dysfunctions like working memory dysfunction and dysfunctions in learning. A major problem in treating schizophrenia is its heterogeneity and patients do not respond the...
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The role of integrase in HIV-1 maturation
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Noa Čemeljić Integrase (IN) is one of the most important enzymes in the replication of the HIV-1 virus, as it integrates viral DNA (vDNA) into the genome of the host cells. However, recent studies have suggested a new surprising role of IN in HIV-1 maturation. If IN is inhibited either by mutations or by allosteric integrase inhibitors (ALLINIs), viral ribonucleoprotein complexes (vRNPs) are often eccentrically localized outside of the capsid (CA). Such viral particles are non-infectious and are blocked...
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The role of optineurin in phagocytosis of fibrillar
amyloid beta in bone marrow-derived macrophages and
dendritic cells
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Bruno Komušanac Optineurin is a multifunctional ubiquitin-binding adaptor protein involved in
regulation of cellular processes, for instance vesicle trafficking, autophagy
and inflammatory signalling. The mutations of the OPTN gene that encodes
for optineurin were linked to several neurodegenerative diseases, the most
important being amyotrophic lateral sclerosis (ALS), which leads to
destruction of motor neurons. Research has shown that phagocytosis, a
process of internalizing and degrading...
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The role of optineurin in the process of phagocytosis
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Katarina Bulić Optineurin is an adaptor protein implicated in multiple cellular processes, such as autophagy, vesicular trafficking, exocytosis, and inflammation. Mutations in the optineurin gene have been linked with amyotrophic lateral sclerosis (ALS), a neurodegenerative disease impacting motor neurons. Previous research has found that phagocytosis, the process of removing extracellular particles by professional phagocytic cells, was disrupted in ALS, and research from our laboratory on cell lines has...
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Toksičnost 3-piridilporfirina u in vivo modelu Drosophila melanogaster
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Sara Čabrijan Porfirini su skupina organskih spojeva, koja se posljednjih godina sve više koristi kao fotosenzibilizator (PS) u fotodinamičkoj terapiji (PDT). PDT se bazira na mehanizmu fototoksične ekscitacije PS-a uz pomoć svjetlosti prikladne valne duljine, čime nastaju reaktivne kisikove vrste odgovorne za citotoksičnost. U pretkliničkim istraživanjima korištenjem in vitro i in vivo pristupa potrebno je dokazati fototoksičnost PS-a samo u prisustvu ekscitacijske valne duljine, kao i...
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Transfer tehnologije u biotehnologiji
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Ivana Abramac Biotehnologija je 1980-ih prepoznata i prihvaćena kao strateška tehnologija od strane većine industrijaliziranih zemalja, a do danas je dotakla ljudske živote u svim aspektima. Najveći utjecaj biotehnologije vidljiv je u zdravstvenom sektoru gdje se kontinuirano radi na istraživanju i razvoju novih lijekova i terapija. Biotehnologija se smatra važnim sredstvom stimuliranja gospodarstva na nacionalnoj i globalnoj razini i jednom od najbrže rastućih inovativnih industrija.
Transfer...
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Transfer tehnologije u farmaceutskoj industriji
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Marina Matulja Svjetska populacija suočava se sa sve većim starenjem stanovništva i povećanim brojem kroničnih oboljenja. Spas za to predstavlja razvitak novih lijekova i terapija. Farmaceutska industrija i njena dostignuća danas stoga predstavljaju ključ za poboljšanje zdravlja i kvalitete života na globalnoj razini. S obzirom na kompleksnost procesa kojim novi lijek dolazi na tržište potrebna je suradnja više različitih industrijskih sektora, a kako bi se cjelokupni proces olakšao i ubrzao...
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Transkripcijski faktor c-Myc kao meta u terapiji raka dojke
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Marina Rončević Transkripcijski faktori imaju važnu ulogu u normalnom funkcioniranju stanice, utječu na stanični ciklus, metabolizam i druge stanične procese. No, njihova amplifikacija i deregulacija može dovesti do razvoja povoljnih uvjeta za nekontroliran rast i razvoj stanica raka. S obzirom na to da je učestalost razvoja kemorezistencije na postojeću terapiju u brojnim malignim bolestima sve veća te su postojeći lijekovi izrazito citotoksični, potreban je razvoj novih strategija za njihovo...
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Treatment options for seasonal affective disorder
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Anja Horvat Seasonal affective disorder (SAD) is a subtype of major depressive disorder. It is a multifactorial disorder characterised by the seasonal appearance of its symptoms such as depressed mood, hypersomnia or insomnia, increased or reduced appetite... There are two types of seasonal affective disorder, based on the season when the symptoms appear – summer and winter type. The cause of the disorder has not yet been found, but there are a couple of hypotheses that suggest the possible origin of...
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Tripiridilporfirin u fotodinamičkoj inaktivaciji biofilma
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Iva Ćavar Legionella pneumophila Gram-negativna je bakterija koja spada u porodicu Legionellaceae. Uzročnik je pontijačke groznice i legionarske bolesti. Obitava u vodenom okruženju kao što su jezera, rijeke, ali i umjetno stvoreni vodeni sustavi kao što su sustavi s visokim temperaturama vode, sustavi rashladne vode, spa i wellness centri, hoteli, bolnice, vodeni sustavi u stomatološkim ordinacijama. U takvom okruženju stvaraju se biofilmovi koje nastanjuje L. pneumophila i u njima se...
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