Prolonged exposure to low doses of mycotoxins poses a risk for kidney disease. The most important mycotoxins which contaminate foodstuffs for human and animal consumption and cause mycotoxicosis are produced by molds of the genera Aspergillus, Penicillium and Fusarium. The entry of mycotoxins into the renal proximal tubules (PT) epithelial cells is mediated by organic anions transporters (Oat), and the accumulation of mycotoxins in the PT is a prerequisite for their toxic effect. The aim of this study was to investigate the individual and combined effects of ochratoxin A (OTA) and citrinin (CIT) after 21 day exposure and the possible protective/reparative effect of resveratrol (RSV) on expression pattern of housekeeping (rNa / K- ATPase and rβ-actin) and Oat protein (rOat1, rOat2, rOat3 and rOat5) in rat kidneys by western and immunocytochemical analysis. OTA (0.125 mg/kg bw or 0.250 mg/kg bw) reduced the expression of rOat1 but not rOat3 and rOat5 protein, depending on the dose, while the expression of rOat2 protein decreased with a higher dose of OTA (0.250 mg/kg bw). CIT treatment (2 mg/kg bw) reduced the expression of rOat2 and rOat5, but not rOat1 and rOat3 proteins. A mixture of mycotoxins (0.250 mg/kg bw OTA + 2 mg/kg bw CIT) decreased rOat1, rOat2 and rOat5 expression and increased rOat3 protein expression. Treatment with OTA or CIT, as well as their mixture, did not alter the expression of housekeeping protein, except for a mixture of mycotoxins with a higher dose of OTA that reduced rβ-actin expression. RSV treatment (0.250 mg/kg bw OTA + 2 mg/kg CIT + 20 mg/kg bw RSV) did not reduce the nephrotoxic effects of mycotoxins. The data obtained indicate the importance of mycotoxin interactions in the regulation of rOat protein expression in rat kidneys.