Methamphetamine (METH) is a psychostimulant that leads to the development of addiction. Our preliminary results showed that METH leads to changes in the number of male fruit fly offspring. The development cycle is connected with metabolism, and thus with the development of reactive oxidation species. METH increases the generation of reactive oxygen species (ROS) and interferes with their removal, causing oxidative stress. Quercetin (QUE) is a molecule with known antioxidant properties that could potentially act on METH-induced changes in the developmental cycle. The aim of the experimental work was to examine how changes in oxidation status (QUE) affect the number of offspring of males exposed to vMETH. METH was administered to a group of males using the FlyBong method, after which 20% of males with the highest locomotor response to METH were selected. Males were mated with untreated females on food with different concentrations of QUE (0.6 mM and 3.2 mM). The influence of QUE on the number of offspring was monitored over three generations. The results showed a statistically significant increase in the number of embryos of the first generation in the group that was exposed to METH, as well as a trend of an increased number of cocoons and flies. The effects of METH were not transmitted to subsequent generations, while the influence of QUE was visible in the second but not the third generation. The results suggest a potential transgenerational influence of QUE on redox balance. In order to statistically confirm these results, the experiment needs to be repeated with an increased number of replicates and an improved food formulation.