The consumption of narcotic drugs affects dopamine and serotonin neurotransmission and is a significant factor in the development of addiction. Psychostimulants such as methamphetamine (METH) act on centers in the brain responsible for regulating reward and pleasure processing. The rewarding influence of drugs leads to repeated consumption and ultimately to addictive behavior that is tested on laboratory animals as preferential self-administration. Drosophila melanogaster is a well-known model organism for studying addictive behavior. In the conducted experiment we used fumin (fmn) mutants of Drosopila melanogaster as a model organism for testing the preferential consumption of METH. We were interested to test the preferential administration in flies that, due to a mutation in the genes for the dopamine transporter (DAT), have disturbed homeostasis in the dopamine system. The method used to test preferential consumption is the Fly CAFE (Capillary Feeder) assay in which the flies had a choice between a sugar solution and a sugar solution with the addition of METH. We found that dopamine plays a key role in the preferential consumption of METH. fmn flies develop an aversive to neutral response to a sugar solution containing METH. A significant statistical difference in preference for METH was also shown between wild type flies (wt) with normal dopamine system function and fmn with with an inactive DAT. Further research and understanding of self-administration of narcotic drugs and their rewarding effects will be useful in design of appropriate pharmacological treatments for the treatment and prevention of addiction.