Nowadays, dietary supplements whose purpose is to reduce body weight are considerably widespread. The action of such supplements is based on a false sense of satiety. The active drug for weight loss is sibutramine that acts on the mechanism of re-absorption of serotonin and norepinephrine. Sibutramine, according to a structure similar to amphetamines, therefore belongs to strictly controlled substances. In the last 15 years, a large number of cases of heart attacks and brain drops occurred in people who consumed drugs whose active substance is sibutramine. After the research has been carried out, the European Medicines Agency has suspended the distribution of drugs across Europe. Soon after the withdrawal of the drugs from the market, substantial concentrations of sibutramine were found in various dietary supplements such as green coffee, weight loss teas, etc., declared as natural products. Counterfeiting of medicines and food supplements is an increasing global problem that can result in disruption of patient safety and health. This research will be conducted by identification and content determination of sibutramine in dietary supplements from the Croatian market by liquid chromatography technique(HPLC). It is well known that consuming 10 mg of sibutramine daily leads to significant side effects such as increased blood pressure, increased heart rate, heart attack and stroke. Eight samples of dietary supplements collected on the Croatian market were tested and none of the respondents gave positive results on sibutramine.