prikaz prve stranice dokumenta Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
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Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
Diagnostic Pathology, 6 (2011), 108; 1-8. https://doi.org/10.1186/1746-1596-6-108
Dekanic, Andrea; Dintinjana, Renata Dobrila; Budisavljevic, Ivana; Pecanic, Sanja; Zuvic Butorac, Marta; Jonjic, Nives

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Dekanic, A., Dintinjana, R. D., Budisavljevic, I., Pecanic, S., Zuvic Butorac, M. i Jonjic, N. (2011). Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagnostic Pathology, 6. (108), 1-8. doi: 10.1186/1746-1596-6-108

Dekanic, Andrea, et al. "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification." Diagnostic Pathology, vol. 6, br. 108, 2011, str. 1-8. https://doi.org/10.1186/1746-1596-6-108

Dekanic, Andrea, Renata Dobrila Dintinjana, Ivana Budisavljevic, Sanja Pecanic, Marta Zuvic Butorac i Nives Jonjic. "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification." Diagnostic Pathology 6, br. 108 (2011): 1-8. https://doi.org/10.1186/1746-1596-6-108

Dekanic, A., et al. (2011) 'Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification', Diagnostic Pathology, 6(108), str. 1-8. doi: 10.1186/1746-1596-6-108

Dekanic A, Dintinjana RD, Budisavljevic I, Pecanic S, Zuvic Butorac M, Jonjic N. Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagnostic Pathology [Internet]. 03.11.2011. [pristupljeno 25.04.2024.];6(108):1-8. doi: 10.1186/1746-1596-6-108

A. Dekanic, R. D. Dintinjana, I. Budisavljevic, S. Pecanic, M. Zuvic Butorac i N. Jonjic, "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification", Diagnostic Pathology, vol. 6, br. 108, str. 1-8, Studeni 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:193:972799. [Citirano: 25.04.2024.]

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Podaci o radu
Naslov (engleski)Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
AutorAndrea Dekanic
AutorRenata Dobrila Dintinjana
AutorIvana Budisavljevic
AutorSanja Pecanic
AutorMarta Zuvic Butorac
AutorNives Jonjic
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
Background: Prognostic and predictive significance of epidermal growth factor receptor (EGFR) in colorectal carcinomas (CRCs) is still controversial. The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status of tumor cells. Methods: Immunohistochemical and FISH analysis was performed on 135 archival formalin fixed and paraffin embedded CRCs. Results: Strong membrane and strong nuclear EGFR staining was detected in 16% and 57% of cases, respectively, and strong cyclin-D1 expression in 57% samples. Gene EGFR amplification was identified in 5.9% and polysomy in 7.4% of cases, while 87% showed no EGFR gene changes. A statistically significant difference was only found between tumor grade and expression of membrane EGFR, while nuclear EGFR and cyclin-D1 expression was not associated with the clinicopathologic characteristics analyzed. Tumor cells displaying gene amplification and strong protein membrane EGFR expression overlapped, while EGFR gene status showed no correlation with nuclear EGFR and cyclin-D1. There was no association between membrane EGFR and cyclin-D1, whereas nuclear EGFR expression was strongly related to cyclin-D1 expression. Conclusions: Study results revealed heterogeneity among CRCs, which could have a predictive value by identifying biologically and probably clinically different subsets of tumors with the possibly diverse response to anti-EGFR therapies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiagnostic Pathology
Brojčani podacivol. 6, br. 108, str. 1-8
e-ISSN1746-1596
DOIhttps://doi.org/10.1186/1746-1596-6-108
URN:NBNurn:nbn:hr:193:972799
Datum objave publikacije2011-11-03
URL dokumentahttps://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-6-108
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-09-30 16:07:09