Chronic pain is a pathological condition which affects millions worldwide, posing unique challenges in diagnosis and treatment. Chronic pain is characterized by discomfort or pain that persists even after a typical period of healing and is a result of chronic pathological mechanisms. Although it affects individuals of all ages and genders, research indicates significant variation in how pain is experienced by different demographic groups. Pain is a very complex and individualized phenomenon whose modulation is influenced by biological, psychological and sociocultural factors. Understanding age-sex differences in thresholds could show "who is more sensitive to pain, women or men, older or younger populations". The clinical application of these data is crucial for several reasons, the adjustment of treatment strategies, the potential development of new analgesics that will specialize in specific mechanisms of the pain pathway and the elimination of gender biases during the setting of analgesia and the prescription of treatment. Key