prikaz prve stranice dokumenta SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex
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Scientific paper - Original scientific paper
SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex
Biomolecules, 14 (2024), 1; 1-16. https://doi.org/10.3390/biom14010070
Baričević, Zrinko; Pongrac, Marta; Ivaničić, Matea; Hreščak, Helena; Tomljanović, Ivana; Petrović, Antonela; Cojoc, Dan; Mladinic, Miranda; Ban, Jelena

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Baričević, Z., Pongrac, M., Ivaničić, M., Hreščak, H., Tomljanović, I., Petrović, A. ... Ban, J. (2024). SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex. Biomolecules, 14. (1), 1-16. doi: 10.3390/biom14010070

Baričević, Zrinko, et al. "SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex." Biomolecules, vol. 14, no. 1, 2024, pp. 1-16. https://doi.org/10.3390/biom14010070

Baričević, Zrinko, Marta Pongrac, Matea Ivaničić, Helena Hreščak, Ivana Tomljanović, Antonela Petrović, Dan Cojoc, Miranda Mladinic and Jelena Ban. "SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex." Biomolecules 14, no. 1 (2024): 1-16. https://doi.org/10.3390/biom14010070

Baričević, Z., et al. (2024) 'SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex', Biomolecules, 14(1), pp. 1-16. doi: 10.3390/biom14010070

Baričević Z, Pongrac M, Ivaničić M, Hreščak H, Tomljanović I, Petrović A, and sur.. SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex. Biomolecules [Internet]. 2024 January 05 [cited 2024 November 18];14(1):1-16. doi: 10.3390/biom14010070

Z. Baričević, et al., "SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex", Biomolecules, vol. 14, no. 1, pp. 1-16, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:835646. [Accessed: 18 November 2024]

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Metadata
Title (english)SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex
AuthorZrinko Baričević
AuthorMarta Pongrac
AuthorMatea Ivaničić
AuthorHelena Hreščak
AuthorIvana Tomljanović
AuthorAntonela Petrović
AuthorDan Cojoc
AuthorMiranda Mladinic
AuthorJelena Ban
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Abstract (english)
(1) Background: Central nervous system (CNS) development is characterized by dynamic changes in cell proliferation and differentiation. Key regulators of these transitions are the transcription factors such as SOX2 and SOX9. SOX2 is involved in the maintenance of progenitor cell state and neural stem cell multipotency, while SOX9, expressed in neurogenic niches, plays an important role in neuron/glia switch with predominant expression in astrocytes in the adult brain. (2) Methods: To validate SOX2 and SOX9 expression patterns in developing opossum (Monodelphis domestica) cortex, we used immunohistochemistry (IHC) and the isotropic fractionator method on fixed cortical tissue from comparable postnatal ages, as well as dissociated primary neuronal cultures. (3) Results: Neurons positive for both neuronal (TUJ1 or NeuN) and stem cell (SOX2) markers were identified, and their presence was confirmed with all methods and postnatal age groups (P4-6, P6-18, and P30) analyzed. SOX9 showed exclusive staining in non-neuronal cells, and it was coexpressed with SOX2. (4) Conclusions: The persistence of SOX2 expression in developing cortical neurons of M. domestica during the first postnatal month implies the functional role of SOX2 during neuronal differentiation and maturation, which was not previously reported in opossums.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 14, no. 1, pp. 1-16, 70
p-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom14010070
URN:NBNurn:nbn:hr:193:835646
Publication2024-01-05
ProjectNumber: IP-2016-06-7060
Title (croatian): Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca
Acronym: DefineREgenAgeMode
Leader: Miranda Mladinić
Jurisdiction: Croatia
ProjectNumber: uniri-prirod-18-290-1463
Title (croatian): Identifikacija i kvantifikacija živčanih matičnih stanica novom metodom optimizirane homogenizacije
Leader: Jelena Ban
Jurisdiction: Croatia
ProjectNumber: uniri-biomed-18-258-6427
Title (croatian): Otkrivanje ključnih molekula koje kontroliraju stanične mehanizme neuroprotekcije i neuroregeneracije posredovane proteinima toplinskog stresa nakon in vitro ozljede leđne moždine oposuma
Leader: Miranda Mladinić
Jurisdiction: Croatia
Document URLhttps://www.mdpi.com/2218-273X/14/1/70
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-10 14:50:55