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master's thesis
Sinteza tiazolamidnih derivata teofilin-7-octene kiseline radi ispitivanja bioloških učinaka
2022. urn:nbn:hr:193:666989
Tukara, Tea
University of Rijeka
Faculty of Biotechnology and Drug Development

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Tukara, T. (2022). Sinteza tiazolamidnih derivata teofilin-7-octene kiseline radi ispitivanja bioloških učinaka (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:666989

Tukara, Tea. "Sinteza tiazolamidnih derivata teofilin-7-octene kiseline radi ispitivanja bioloških učinaka." Master's thesis, University of Rijeka, 2022. https://urn.nsk.hr/urn:nbn:hr:193:666989

Tukara, Tea. "Sinteza tiazolamidnih derivata teofilin-7-octene kiseline radi ispitivanja bioloških učinaka." Master's thesis, University of Rijeka, 2022. https://urn.nsk.hr/urn:nbn:hr:193:666989

Tukara, T. (2022). 'Sinteza tiazolamidnih derivata teofilin-7-octene kiseline radi ispitivanja bioloških učinaka', Master's thesis, University of Rijeka, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:193:666989

Tukara T. Sinteza tiazolamidnih derivata teofilin-7-octene kiseline radi ispitivanja bioloških učinaka [Master's thesis]. Rijeka: University of Rijeka; 2022 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:193:666989

T. Tukara, "Sinteza tiazolamidnih derivata teofilin-7-octene kiseline radi ispitivanja bioloških učinaka", Master's thesis, University of Rijeka, Rijeka, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:193:666989

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Metadata
TitleSinteza tiazolamidnih derivata teofilin-7-octene kiseline radi ispitivanja bioloških učinaka
Title (english)Synthesis of thiazole-amide derivatives of theophylline-7-acetic acid to evaluate their biological effects
AuthorTea Tukara
MentorKarlo Wittine (mentor)
Committee memberNela Malatesti (predsjednik povjerenstva)
Committee memberKarlo Wittine (član povjerenstva)
Committee memberIvana Ratkaj (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2022-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U sklopu ovog rada reakcijom amidacije pripravljeni su derivati teofilin-7- octene kiseline: a) tiazolni derivati 1-2, b) benzo[d]tiazolni derivati 3-6 i c) 4-feniltiazolni derivati 7-15. Strukture spojeva potvrđene su spektroskopijom 1H NMR kao i spektrometrijom masa. In silico PASS analizom predviđeni su farmakološki učinci i biološke mete. Većina spojeva prema predviđanju bi trebala posjedovati djelovanje na transkripcijski faktor STAT, cAMP fosfodiesterazu ili posjedovati nootropno djelovanje.
Abstract (english)
As part of this work, theophylline-7-acetic acid derivatives were prepared by te amidation reaction : a) thiazole derivatives 1-2, b) benzo[d]thiazole derivatives 3-6, c) 4-phenylthiazole derivatives 7-15. The structures of the prepared compounds were elucidated by 1H NMR spectroscopy and mass spectrometry. Pharmacological effects and potential biological targets of novel compounds have been predicted by in silico analysis (PASS). Most compounds are predicted to have activity on transcription factor STAT, cAM phosphodiesterase, or posses nootropic activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:666989
Study programmeTitle: Medicinal chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-10-24
Terms of useLicence In copyright icon
Created on2022-10-24 12:49:47