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undergraduate thesis
Drug-induced and genetic mice models of mania in bipolar disorder
2021. urn:nbn:hr:193:148546
Kršanac, Matea
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Kršanac, M. (2021). Drug-induced and genetic mice models of mania in bipolar disorder (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:148546

Kršanac, Matea. "Drug-induced and genetic mice models of mania in bipolar disorder." Undergraduate thesis, University of Rijeka, 2021. https://urn.nsk.hr/urn:nbn:hr:193:148546

Kršanac, Matea. "Drug-induced and genetic mice models of mania in bipolar disorder." Undergraduate thesis, University of Rijeka, 2021. https://urn.nsk.hr/urn:nbn:hr:193:148546

Kršanac, M. (2021). 'Drug-induced and genetic mice models of mania in bipolar disorder', Undergraduate thesis, University of Rijeka, accessed 31 December 2024, https://urn.nsk.hr/urn:nbn:hr:193:148546

Kršanac M. Drug-induced and genetic mice models of mania in bipolar disorder [Undergraduate thesis]. Rijeka: University of Rijeka; 2021 [cited 2024 December 31] Available at: https://urn.nsk.hr/urn:nbn:hr:193:148546

M. Kršanac, "Drug-induced and genetic mice models of mania in bipolar disorder", Undergraduate thesis, University of Rijeka, Rijeka, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:193:148546

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Metadata
TitleDrug-induced and genetic mice models of mania in bipolar disorder
Title (croatian)Lijekovima inducirani i genetički modeli miševa manične faze bipolarnog poremećaja
AuthorMatea Kršanac
MentorNicholas James Bradshaw (mentor)
Committee memberIvana Ratkaj (predsjednik povjerenstva)
Committee memberRozi Andretić Waldowski (član povjerenstva)
Committee memberNicholas James Bradshaw (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2021-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Bipolar disorder is a psychiatric disorder that greatly affects a patient’s day-to-day functioning and is characterised by recurrent manic and depressive episodes. Current mania treatments do not show efficacy for all patients, increasing the need for targeted therapeutic development. The drug development process includes its assessment using applicable animal models, which are sparse for mania in bipolar disorder. An ideal mouse model of mania should fulfil the three validity criteria, as well as display specific endophenotypes comparable to those in human patients. In the thesis, I reviewed some suggested mice models of mania in bipolar disorder, which are either a result of genetic manipulations or induced by drug administration. Single genetic manipulations focused on genes related to the circadian rhythm and dopaminergic, serotonergic, and glutamatergic systems resulted in mice models such as the Clock Δ19 and DAT knockdown mutant mice, which show a limited number of symptoms, predominantly locomotor hyperactivity. In comparison, an amphetamine-induced mouse model of mania showed limited results, suggesting that genetic models are more appropriate. The complex symptomatology of mania has yet to be fully reflected successfully in mouse models, which are mostly based on simple behavioural abnormalities. Regardless, the mutual comparison and assessment of known models allows the establishment of future directions in mouse model of mania development. Highlighting the use of multivariate approaches such as genetic information from human studies, extensive behavioural testing, and objective quantification of behaviours with cross-species paradigms will enable further advancement towards an ideal model of mania.
Abstract (croatian)
Bipolarni poremećaj je psihijatrijski poremećaj koji uvelike utječe na svakodnevne funkcije pacijenta i karakteriziran je ponavljajućim epizodama manije i depresije. Trenutno dostupni tretmani manije nisu učinkoviti za sve pacijente, uvelike povećavajući potrebu za razvojem ciljanih terapija. Proces razvoja lijekova uključuje njegovo testiranje na odgovarajućim životinjskim modelima koji su rijetki za maniju u bipolarnom poremećaju. Idealni mišji model manije trebao bi zadovoljavati tri kriterija valjanosti, kao i prikazati specifične endofenotipove usporedive s onima zabilježenim kod ljudskih pacijenata. Ovaj rad uključuje pregled nekih od predloženih mišjih modela manije, koji su produkt genetskih manipulacija ili inducirani administracijom lijekova. Pojedinačne genetske manipulacije usredotočene na gene povezane s cirkadijalnim ritmom te dopaminergičkim, serotonergičkim i glutamatergičnim sustavima rezultirale su mišjim modelima kao što su Clock Δ19 i DAT knockdown mutantski miševi, koji pokazuju ograničen broj simptoma, pretežno lokomotornu hiperaktivnost. Za razliku od njih, amfetaminom induciran mišji model manije pokazao je ograničene rezultate, ukazujući na to da su genetski modeli prikladniji za primjenu. Složena simptomatologija manije još nije u potpunosti odražena u mišjim modelima, koji se uglavnom temelje na jednostavnim poremećajima u ponašanju. Bez obzira na to, međusobno uspoređivanje i procjena poznatih modela omogućuje uspostavljanje budućih pravaca u razvoju mišjeg modela manije. Uporaba multivarijantnih pristupa, kao što su korištenje genetskih informacija iz ljudskih istraživanja, razvoj opsežnih testova ponašanja te objektivna kvantifikacija ponašanja u kombinaciji sa razvojem međuvrsnih paradigmi omogućit će daljnji napredak u dizajnu idealnog modela manije.
Keywords
Keywords (croatian)
Languagecroatian
URN:NBNurn:nbn:hr:193:148546
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-09-20 13:59:03