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undergraduate thesis
Uloga mikrookoliša tumora u razvoju kemorezistencije
2018. urn:nbn:hr:193:034613
Žgela, Tonka
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Žgela, T. (2018). Uloga mikrookoliša tumora u razvoju kemorezistencije (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:034613

Žgela, Tonka. "Uloga mikrookoliša tumora u razvoju kemorezistencije." Undergraduate thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:034613

Žgela, Tonka. "Uloga mikrookoliša tumora u razvoju kemorezistencije." Undergraduate thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:034613

Žgela, T. (2018). 'Uloga mikrookoliša tumora u razvoju kemorezistencije', Undergraduate thesis, University of Rijeka, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:193:034613

Žgela T. Uloga mikrookoliša tumora u razvoju kemorezistencije [Undergraduate thesis]. Rijeka: University of Rijeka; 2018 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:193:034613

T. Žgela, "Uloga mikrookoliša tumora u razvoju kemorezistencije", Undergraduate thesis, University of Rijeka, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:193:034613

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Metadata
TitleUloga mikrookoliša tumora u razvoju kemorezistencije
Title (english)The role of tumor microenvironment in development of chemoresistance
AuthorTonka Žgela
MentorMirela Sedić (mentor)
Committee memberElitza Petkova Markova-Car (predsjednik povjerenstva)
Committee memberIvana Ratkaj (član povjerenstva)
Committee memberMirela Sedić (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2018-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Mnoga istraživanja potvrdila su kompleksnost tumora kojeg ne čine samo tumorske stanice, nego i mikrookoliš koji se sastoji od stromalnih stanica (fibroblasta, imunih stanica, endotelnih stanica, mezenhimalnih matičnih stanica, adipocita) i izvanstaničnog matriksa. Putem raznih faktora i enzima koje luče, kao što su IL-6, TGF- β, MMPs, HIF-1 potiču proliferaciju tumora, angiogenezu i kemorezistenciju. CAFs su najmnogobrojnije stanice u tumorskom mikrookolišu te bi se njih trebalo posebno uzeti u obzir pri istraživanju novih terapija. Mikrookoliš utječe na agresivnost i metastaziranje tumora, a kroz interakcije sa stanicama raka putem različitih signalnih puteva omogućava uvjete za proliferaciju tumora i zaštitu stanica raka od kemoterapeutika.
Abstract (english)
Many reports revealed complexity of tumor which is composed not only of cancer cells, but also of microenvironment which contains stromal cells (fibroblasts, immune cells, endothelial cells, mesenchymal stem cells, adypocytes), extracellular matrix. By release of different soluble factors and enzymes, such as IL-6, TGF- β, MMPs, HIF-1 they promote tumor proliferation, angiogenesis and chemoresistance. CAFs are the most numerous cells in microenvironment so there should be special attention payed to them when creating new cancer therapies. Tumor microenvironment can affect how aggressive and metastatic tumor can get and by interacting with cancer cells through different signaling pathways can promote tumor proliferation and protection of tumor cells from chemotherapeutics.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:034613
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-11-06 07:56:46