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Scientific paper - Original scientific paper
The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation
International Journal of Endocrinology, 2013 (2013); 637919. https://doi.org/10.1155/2013/637919
Alebić, Miro Šimun; Stojanović, Nataša; Žuvić-Butorac, Marta

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Alebić, M. Š., Stojanović, N. & Žuvić Butorac, M. (2013). The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation. International Journal of Endocrinology, 2013.. doi: 10.1155/2013/637919

Alebić, Miro Šimun, et al. "The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation." International Journal of Endocrinology, vol. 2013, 2013. https://doi.org/10.1155/2013/637919

Alebić, Miro Šimun, Nataša Stojanović and Marta Žuvić Butorac. "The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation." International Journal of Endocrinology 2013 (2013). https://doi.org/10.1155/2013/637919

Alebić, M. Š., Stojanović, N. and Žuvić Butorac, M. (2013) 'The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation', International Journal of Endocrinology, 2013. doi: 10.1155/2013/637919

Alebić MŠ, Stojanović N, Žuvić Butorac M. The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation. International Journal of Endocrinology [Internet]. 2013 [cited 2025 January 09];2013. doi: 10.1155/2013/637919

M. Š. Alebić, N. Stojanović and M. Žuvić Butorac, "The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation", International Journal of Endocrinology, vol. 2013, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:368611. [Accessed: 09 January 2025]

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Metadata
Title (english)The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation
AuthorMiro Šimun Alebić https://orcid.org/0000-0002-3358-5055
AuthorNataša Stojanović https://orcid.org/0000-0001-8053-4771
AuthorMarta Žuvić-Butorac https://orcid.org/0000-0001-9709-1508
MBZ: 173412
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Objective. To investigate the endocrine and/or clinical characteristics of women with low anti-Müllerian hormone (AMH) that could improve the accuracy of IVF outcome prediction based on the female age alone prior to the first GnRH antagonist IVF cycle. Methods. Medical records of 129 patients with low AMH level (<6.5 pmol/L) who underwent their first GnRH antagonist ovarian stimulation protocol for IVF/ICSI were retrospectively analyzed. The main outcome measure was the area under the ROC curve (AUC-ROC) for the models combining age and other potential predictive factors for the clinical pregnancy. Results. Clinical pregnancy rate (CPR) per initiated cycles was 11.6%. For the prediction of clinical pregnancy, DHEAS and age showed AUC-ROC of 0.726 (95%CI 0.641–0.801) and 0.662 (95%CI 0.573–0.743), respectively. The predictive accuracy of the model combining age and DHEAS (AUC-ROC 0.796; 95%CI 0.716–0.862) was significantly higher compared to that of age alone (). In patients <37.5 years with DHEAS  pmol/L, 60% (9/15) of all pregnancies were achieved with CPR of 37.5%. Conclusions. DHEAS appears to be predictive for clinical pregnancy in younger women (<37.5 years) with low AMH after the first GnRH antagonist IVF cycle. Therefore, DHEAS-age model could refine the pretreatment counseling on pregnancy prospects following IVF.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Endocrinology
Numberingvol. 2013, 637919
BPC800 USD
p-ISSN2224-0721
e-ISSN2307-1427
DOIhttps://doi.org/10.1155/2013/637919
URN:NBNurn:nbn:hr:193:368611
Publication2013
Document URLhttps://www.hindawi.com/journals/ije/apc/
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-09-30 12:18:49