prikaz prve stranice dokumenta In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism
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Scientific paper - Original scientific paper
In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism
ChemMedChem, 13 (2018), 4; 360-372. https://doi.org/10.1002/cmdc.201700748
Jelovica, Mateo; Grbčić, Petra; Mušković, Martina; Sedić, Mirela; Pavelić, Sandra Kraljević; Lončarić, Martin; Malatesti, Nela

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Jelovica, M., Grbčić, P., Mušković, M., Sedić, M., Pavelić, S. K., Lončarić, M. & Malatesti, N. (2018). In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism. ChemMedChem, 13. (4), 360-372. doi: 10.1002/cmdc.201700748

Jelovica, Mateo, et al. "In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism." ChemMedChem, vol. 13, no. 4, 2018, pp. 360-372. https://doi.org/10.1002/cmdc.201700748

Jelovica, Mateo, Petra Grbčić, Martina Mušković, Mirela Sedić, Sandra Kraljević Pavelić, Martin Lončarić and Nela Malatesti. "In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism." ChemMedChem 13, no. 4 (2018): 360-372. https://doi.org/10.1002/cmdc.201700748

Jelovica, M., et al. (2018) 'In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism', ChemMedChem, 13(4), pp. 360-372. doi: 10.1002/cmdc.201700748

Jelovica M, Grbčić P, Mušković M, Sedić M, Pavelić SK, Lončarić M, and sur.. In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism. ChemMedChem [Internet]. 2018 [cited 2024 November 17];13(4):360-372. doi: 10.1002/cmdc.201700748

M. Jelovica, et al., "In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism", ChemMedChem, vol. 13, no. 4, pp. 360-372, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:812786. [Accessed: 17 November 2024]

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Title (english)In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism
AuthorMateo Jelovica
AuthorPetra Grbčić
AuthorMartina Mušković
AuthorMirela Sedić
AuthorSandra Kraljević Pavelić
AuthorMartin Lončarić
AuthorNela Malatesti
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Abstract (english)
A series of N-methylated and N-oxidised tripyridyl porphyrins were synthesised, characterised, and their PDT activity was studied with six cell lines. All the tested porphyrins with a long alkyl chain, except one, were more efficient for PDT than an N- methylated hydrophilic porphyrin and N-oxidised porphyrin without the long alkyl chain. Generally, N-methylated tripyridyl porphyrins were more active than those N-oxidised, but IC50 values for phototoxicity of two N-oxides, named TOPyP3-C17H33O and TOPyP3-C17H35, were still in the nanomolar concentration range for most of the tested cell lines. However, TOPyP3- C17H35 did not show phototoxicity on human foreskin fibroblast cells. Two methylated amphiphilic porphyrins, named TMPyP3-C17H33 and TMPyP4-C17H35, showed significant dark toxicity, whereas none of the oxidopyridyl porphyrins were toxic without light activation. The selected photosensitisers were shown to be apoptosis inducers, and had inhibitory effects on the clonogenic growth of HCT116 and HeLa cells. All three N-methylated amphiphilic porphyrins significantly reduced the migratory potential of HCT116 cells. Porphyrins TMPyP3- C17H35 and TOPyP3-C17H35 reduced the activity of acid ceramidase, whereas TOPyP3-C17H33O had a significant inhibitory effect on sphingosine kinase 1 activity in HeLa cells. Compounds with this dual activity were shown to be the most promising photosensitisers, with potential to treat invasive cancers.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionSubmitted version
Journal titleChemMedChem
Numberingvol. 13, no. 4, pp. 360-372
p-ISSN1860-7179
DOIhttps://doi.org/10.1002/cmdc.201700748
URN:NBNurn:nbn:hr:193:812786
Publication2018
Document URLhttp://bib.irb.hr/922747
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2018-09-13 13:45:23