prikaz prve stranice dokumenta Studij sinteze konjugata azitromicina i klorina e6
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master's thesis
Studij sinteze konjugata azitromicina i klorina e6
2017. urn:nbn:hr:193:074601
Lijić, Martina
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Lijić, M. (2017). Studij sinteze konjugata azitromicina i klorina e6 (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:074601

Lijić, Martina. "Studij sinteze konjugata azitromicina i klorina e6." Master's thesis, University of Rijeka, 2017. https://urn.nsk.hr/urn:nbn:hr:193:074601

Lijić, Martina. "Studij sinteze konjugata azitromicina i klorina e6." Master's thesis, University of Rijeka, 2017. https://urn.nsk.hr/urn:nbn:hr:193:074601

Lijić, M. (2017). 'Studij sinteze konjugata azitromicina i klorina e6', Master's thesis, University of Rijeka, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:193:074601

Lijić M. Studij sinteze konjugata azitromicina i klorina e6 [Master's thesis]. Rijeka: University of Rijeka; 2017 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:193:074601

M. Lijić, "Studij sinteze konjugata azitromicina i klorina e6", Master's thesis, University of Rijeka, Rijeka, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:193:074601

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Metadata
TitleStudij sinteze konjugata azitromicina i klorina e6
Title (english)Azithromycin and chlorine e6 conjugate synthesis study
AuthorMartina Lijić
MentorDavor Margetić (mentor)
MentorKarlo Wittine (mentor)
Committee memberDavor Margetić (predsjednik povjerenstva)
Committee memberKarlo Wittine (član povjerenstva)
Committee memberRoberto Antolović (član povjerenstva)
Committee memberElitza Petkova Markova - Car (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2017-10-31, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U ovom radu opisan je razvoj sinteze novoga konjugata azitromicina i klorina e6. Pripravljeni derivat azitromicina s aktiviranom 4''-O-acilimidazolilnom funkcionalnom skupinom i 13¹-etilendiaminski derivat klorina e6 su reakcijom amidnog vezanja u završnom stupnju paralelne sinteze povezani u željeni konjugat. Svim izoliranim spojevima strukture su potvrđene i okarakterizirane 1H i 13C NMR, UV/Vis i IR spektrima a završnom spoju 21 dodatno i 2D spektroskopijom COSY, NOESY i TOCSY. Svrha je sintetiziranih spojeva ispitivanje mogućnosti njihova korištenja u antimikrobnoj fotodinamičkoj terapiji.
Abstract (english)
This work describes the synthesis of a new conjugate of azithromycin and chlorine e6. The prepared azithromycin derivative with the activated 4"-O-acylimidazolyl functional group and the 13-ethylenediamine derivative of chlorine e6 are reacted with the amide bond in the final step of the parallel synthesis linked to the desired conjugate. All isolated structural compounds were confirmed and characterized by 1H and 13C NMR, UV/Vis and IR spectra and final compound 21 in addition to 2D COSY, NOESY and TOCSY spectroscopy. The purpose of the synthesized compounds is to investigate the possibility of their use in antimicrobial photodynamic therapy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:074601
Study programmeTitle: Medicinal chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-01-15 09:16:09