Zeolites are a heterogeneous group of minerals that differ in their chemical and physical properties. They are hydrated microporous crystals with a clearly defined structure consisting of AlO4 and SiO4 tetrahedra linked through oxygen atoms. The open structure allows the integration of different cations such as Na⁺, K⁺, Ca²⁺ and Mg²⁺. The most common zeolites in nature are clinoptilolite and mordenite, and clinoptilolite is the only one currently used in medicine, since it is considered not to be toxic and to have a positive effect on human and animal health. Natural micronized clinoptilolite has positive effects on immune and inflammatory processes due to its ability to maintain chemical and biological stability, and to selectively bind molecules of specific forms and sizes. In this study, we used Drosophila melanogaster as a model organism, whose main advantage is its genetic approach. The purpose of this study was to examine the antioxidant activity of clinoptilolite materials by determining their influence on the antioxidative defense mechanism and redox status. We investigated the activity of three types of clinoptilolite materials : Raw, PMA and PMAO₂, on oxidative stress and aging process. Given the connection between circadian and redox regulation, we investigated the correlation of the circadian period protein with the activity of antioxidative enzymes catalase and superoxide dismutase. The obtained results showed that the positive effects of the examined clinoptilolite materials differed based on measured properties and phenotypes. Raw showed the highest antioxidative capacity and PMA increased negative geotaxis in young flies, while both showed a positive effect in delaying the induced aging process. PMAO₂ increased negative geotaxis score after two weeks of treatment, compared to untreated flies. All tested clinoptilolite materials reduced the activity of antioxidative enzymes CAT and SOD after two weeks of treatment and increased the amount of period protein, indicating the negative correlation between these two phenotypes. This is the first research showing the association between clinoptilolite, its potential antioxidant activity and the regulation of circadian genes, as well as first such research on Drosophila.