prikaz prve stranice dokumenta Unveiling the link between normal development and brain cancer formation
  Download
PDF 487.93 KB
undergraduate thesis
Unveiling the link between normal development and brain cancer formation
2024. urn:nbn:hr:193:012811
Dragoslavić, Lara
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Dragoslavić, L. (2024). Unveiling the link between normal development and brain cancer formation (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:012811

Dragoslavić, Lara. "Unveiling the link between normal development and brain cancer formation." Undergraduate thesis, University of Rijeka, 2024. https://urn.nsk.hr/urn:nbn:hr:193:012811

Dragoslavić, Lara. "Unveiling the link between normal development and brain cancer formation." Undergraduate thesis, University of Rijeka, 2024. https://urn.nsk.hr/urn:nbn:hr:193:012811

Dragoslavić, L. (2024). 'Unveiling the link between normal development and brain cancer formation', Undergraduate thesis, University of Rijeka, accessed 21 September 2024, https://urn.nsk.hr/urn:nbn:hr:193:012811

Dragoslavić L. Unveiling the link between normal development and brain cancer formation [Undergraduate thesis]. Rijeka: University of Rijeka; 2024 [cited 2024 September 21] Available at: https://urn.nsk.hr/urn:nbn:hr:193:012811

L. Dragoslavić, "Unveiling the link between normal development and brain cancer formation", Undergraduate thesis, University of Rijeka, Rijeka, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:193:012811

Please login to the repository to save this object to your list.
Metadata
TitleUnveiling the link between normal development and brain cancer formation
Title (croatian)Otkrivanje veze između normalnog razvoja i nastanka raka mozga
AuthorLara Dragoslavić
MentorKatarina Kapuralin (mentor)
Committee memberMladen Merćep (predsjednik povjerenstva)
Committee memberŽeljka Minić (član povjerenstva)
Committee memberKatarina Kapuralin (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Neural stem cells are a group of cells capable of self-renewal and differentiation into various subtypes. Proper regulation of these cells is essential for normal development and function of the central nervous system. When this regulation fails, it can result in the formation of tumors, such as gliomas. In this thesis, we tried to clarify the relationship between neurogenesis and tumor formation, emphasizing the molecular and cellular mechanisms that potentially drive the process of tumorigenesis. By synthesizing current research on the expression of transcription factors and genes involved in both neurogenesis and tumorigenesis, this thesis aims to highlight critical pathways and factors in brain tumor development. Identifying the cell of origin for each tumor type can reveal lineage-specific therapeutic vulnerabilities and opportunities to detect early malignant or even premalignant abnormal cell states, as certain cells may be more susceptible to oncogenic attacks than others. Understanding these mechanisms may reveal new therapeutic targets and strategies for preventing and treating brain cancer.
Abstract (croatian)
Neuralne matične stanice su skupina stanica koja ima sposobnost samoobnavljanja i diferencijacije u različite podtipove. Pravilna regulacija ovih stanica ključna je za normalan razvoj i funkcioniranje središnjeg živčanog sustava. Kada ova regulacija zakaže, to može rezultirati formiranjem tumora, kao što su gliomi. U ovom radu, pokušali smo razjasniti odnos između neurogeneze i nastanka tumora, ističući molekularne i stanične mehanizme koji potencijalno pokreću proces tumorigeneze. Pregledom trenutnih istraživanja o ekspresiji transkripcijskih faktora i gena uključenih i u neurogenezu i u tumorigenezu, ovaj rad nastoji istaknuti ključne puteve i faktore u razvoju tumora mozga. Identificiranje podrijetla stanice za svaku vrstu tumora može otkriti specifične terapijske slabosti i mogućnost ranog otkrivanja malignih ili čak pre-malignih abnormalnih stanja stanica, budući da određene stanice mogu biti osjetljivije na onkogene napade od drugih. Razumijevanje ovih mehanizama može otkriti nove terapijske mete i strategije za prevenciju i liječenje raka mozga.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:193:012811
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-08 15:12:03