prikaz prve stranice dokumenta Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study
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Scientific paper - Original scientific paper
Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study
Pharmaceuticals, 16 (2023), 2; 251-269. https://doi.org/10.3390/ph16020251
Novak, Jurica; Tseilikman, Vadim E.; Tseilikman, Olga B.; Lazuko, Svetlana S.; Belyeva, Lyudmila E.; Rahmani, Azam; Fedotova, Julia

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Novak, J., Tseilikman, V. E., Tseilikman, O. B., Lazuko, S. S., Belyeva, L. E., Rahmani, A. & Fedotova, J. (2023). Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study. Pharmaceuticals, 16. (2), 251-269. doi: 10.3390/ph16020251

Novak, Jurica, et al. "Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study." Pharmaceuticals, vol. 16, no. 2, 2023, pp. 251-269. https://doi.org/10.3390/ph16020251

Novak, Jurica, Vadim E. Tseilikman, Olga B. Tseilikman, Svetlana S. Lazuko, Lyudmila E. Belyeva, Azam Rahmani and Julia Fedotova. "Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study." Pharmaceuticals 16, no. 2 (2023): 251-269. https://doi.org/10.3390/ph16020251

Novak, J., et al. (2023) 'Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study', Pharmaceuticals, 16(2), pp. 251-269. doi: 10.3390/ph16020251

Novak J, Tseilikman VE, Tseilikman OB, Lazuko SS, Belyeva LE, Rahmani A, and sur.. Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study. Pharmaceuticals [Internet]. 2023 February 07 [cited 2024 April 19];16(2):251-269. doi: 10.3390/ph16020251

J. Novak, et al., "Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study", Pharmaceuticals, vol. 16, no. 2, pp. 251-269, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:201396. [Accessed: 19 April 2024]

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Metadata
Title (english)Can Resveratrol Influence the Activity of 11β- Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study
AuthorJurica Novak
AuthorVadim E. Tseilikman
AuthorOlga B. Tseilikman
AuthorSvetlana S. Lazuko
AuthorLyudmila E. Belyeva
AuthorAzam Rahmani
AuthorJulia Fedotova
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Theoretical Chemistry
Abstract (english)
The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) is an NADPH-dependent reductase, responsible for the activation of cortisol by reducing cortisone. Resveratrol (RES), a type of natural polyphenol, is reported to be able to slow the progression of cancer and cardiovascular disease and improve the health of mice on a high- calorie diet. In this article, we applied molecular docking and molecular dynamics simulations to investigate the possibility of binding RES to 11β-HSD-1. The 11β-HSD-1:RES complex is stable on the μs time scale, and backbone RMSD-based clustering identified three conformations. Special attention was paid to the interaction pattern between the ligand and the target molecule, revealing hydrogen bonds between the hydroxyl group of RES and Thr124, as well as hydrophobic interactions responsible for the binding. In vivo studies demonstrated the ability of resveratrol at a dose of 40 mg/kg to reduce 11β-HSD-1 activity in the liver of rats under conditions of experimental post-traumatic stress disorder (PTSD), as well as in non-stressed animals. In both cases, the resveratrol-induced reduction in 11β-HSD-1 activity was accompanied by an increase in plasma corticosterone levels and a decrease in anxiety levels in the plus maze test.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePharmaceuticals
Numberingvol. 16, no. 2, pp. 251-269
p-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph16020251
URN:NBNurn:nbn:hr:193:201396
Publication2023-02-07
Document URLhttps://www.mdpi.com/1424-8247/16/2/251
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-02-12 19:24:39