COVID-19 is a disease caused by the SARS-CoV-2 virus that was first detected in the Chinese province of Wuhan in 2019. Due to the fact that it is a virus that spreads very quickly, several pharmaceutical companies have developed vaccines. The aim of this paper is to conduct a survey to assess the concerns and acceptance rates of COVID-19 vaccines among the general population in the Republic of Croatia. It also wants to check whether it is necessary to further inform the public about the safety of available vaccines. Vaccination interest analysis was conducted depending on age and gender, level of education, employment status, and business sector. The next set of questions referred to COVID-19, whether the respondents overcame this disease or someone close to them. The last set of questions examined attitudes about vaccination and available vaccines. The research showed that the opinions of the respondents were divided, namely 49.1% want to be vaccinated and 50.9% refuse to be vaccinated. They are most concerned about the side effects and the speed of vaccine development, and they would only agree to the vaccination after a certain period of time when they would be convinced that the vaccines are safe. Those who have finished high school, and are employed in the trade sector, are the most suspicious. The analysis of the received surveys showed that the respondents want to choose the type of vaccine themselves, and most respondents would choose the Pfizer / BioNTech vaccine, more precisely 48.8%. While, the citizens of the Republic of Croatia have the least trust in vaccines from AstraZeneca and Johnson & Johnson.