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undergraduate thesis
Uloga period gena u malignim bolestima
2020. urn:nbn:hr:193:321297
Tukara, Tea
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Tukara, T. (2020). Uloga period gena u malignim bolestima (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:321297

Tukara, Tea. "Uloga period gena u malignim bolestima." Undergraduate thesis, University of Rijeka, 2020. https://urn.nsk.hr/urn:nbn:hr:193:321297

Tukara, Tea. "Uloga period gena u malignim bolestima." Undergraduate thesis, University of Rijeka, 2020. https://urn.nsk.hr/urn:nbn:hr:193:321297

Tukara, T. (2020). 'Uloga period gena u malignim bolestima', Undergraduate thesis, University of Rijeka, accessed 19 January 2025, https://urn.nsk.hr/urn:nbn:hr:193:321297

Tukara T. Uloga period gena u malignim bolestima [Undergraduate thesis]. Rijeka: University of Rijeka; 2020 [cited 2025 January 19] Available at: https://urn.nsk.hr/urn:nbn:hr:193:321297

T. Tukara, "Uloga period gena u malignim bolestima", Undergraduate thesis, University of Rijeka, Rijeka, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:193:321297

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Metadata
TitleUloga period gena u malignim bolestima
Title (english)The role of period genes in malignancies
AuthorTea Tukara
MentorElitza Petkova Markova - Car (mentor)
Committee memberMirela Sedić (predsjednik povjerenstva)
Committee memberSanja Dević Pavlić (član povjerenstva)
Committee memberElitza Petkova Markova - Car (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2020-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Cirkadijalni ritmovi su fundamentalna osobina života, oni reguliraju biološke procese koji se odvijaju tijekom 24 sata. Fiziološke i psihološke promjene te promjene u ponašanju koje su usklađene s izmjenom dana i noći prate taj 24-satni ciklus. Cirkadijalni sustav uključuje ulazni put koji odašilje signale iz okoline do jezgre oscilatora (SCN) koja generira signale koji su odgovorni za periferne fiziološke ili bihevioralne događaje. Cirkadijalni ritmovi su samoodrživi, a prilagođavaju se signalima iz okoliša uključujući svjetlost, temperaturu i hranu. Poremećaj u cirkadijalnim ritmovima povezan je s nekoliko oblika raka u ljudima. Sve veća disfunkcija rada sata već se pripisuje patogenezi raka, a mnoga su istraživanja otkrila da je deregulacija cirkadijalnih satnih gena uključena u razvoj mnogih bolesti, uključujući zloćudne bolesti. Nekoliko studija otkrilo je da su smanjene razine ekspresije Period gena primijećene u tumorskim tkivima u usporedbi s pripadajućim tumorom nezahvaćenim tkivima kod različitih vrsta raka. Period geni su uključeni u molekularni mehanizam cirkadijalnog sata te pokazuju svojstva tumor supresora, stoga su zanimljivi za proučavanje. Deregulacija ovih gena predviđa smanjeno preživljenje u bolesnika s uznapredovalim karcinomom pluća, bubrega, dojke i debelog crijeva.
Abstract (english)
Circadian rhythms are fundamental feature of life, they regulate biological processes that take place over 24 hours. The circadian system includes an input pathway that perceives signals from the environment and transmits the input signals to the core oscillator (SCN) that generates signals that are responsible for peripheral physiological or behavioral events. Circadian rhythms are self-sustained and adapt to signals from the environment including light, temperature, and food. Disturbances in circadian rhythms have been associated with several forms of cancer in humans. The increasing dysfunction of the clock is already attributed to the pathogenesis of cancer, and many studies have found that deregulation of circadian clock genes is involved in the development of various diseases, including malignancies. Several studies have found reduced levels of Period genes in tumor tissues compared to adjacent nontumorous tissues in different types of cancer. Period genes are involved in the molecular mechanism of circadian clock and show properties of tumor suppressor genes, making them interesting to study. Deregulation of these genes estimates reduced survival rates in patients with advanced lung, kidney, breast, and colon cancers.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:321297
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2020-09-24 14:30:08