prikaz prve stranice dokumenta Utjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima
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undergraduate thesis
Utjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima
2019. urn:nbn:hr:193:618985
Kajzogaj, Isidora
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Kajzogaj, I. (2019). Utjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:618985

Kajzogaj, Isidora. "Utjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima." Undergraduate thesis, University of Rijeka, 2019. https://urn.nsk.hr/urn:nbn:hr:193:618985

Kajzogaj, Isidora. "Utjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima." Undergraduate thesis, University of Rijeka, 2019. https://urn.nsk.hr/urn:nbn:hr:193:618985

Kajzogaj, I. (2019). 'Utjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima', Undergraduate thesis, University of Rijeka, accessed 01 April 2025, https://urn.nsk.hr/urn:nbn:hr:193:618985

Kajzogaj I. Utjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima [Undergraduate thesis]. Rijeka: University of Rijeka; 2019 [cited 2025 April 01] Available at: https://urn.nsk.hr/urn:nbn:hr:193:618985

I. Kajzogaj, "Utjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima", Undergraduate thesis, University of Rijeka, Rijeka, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:193:618985

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Metadata
TitleUtjecaj dopaminskog sistema na neuralnu plastičnost induciranu psihostimulansima
Title (english)Effect of dopaminergic system on psychostimulant – induced neural plasticity
AuthorIsidora Kajzogaj
MentorRozi Andretić Waldowski (mentor)
Committee memberJelena Ban (predsjednik povjerenstva)
Committee memberDaniela Kalafatović (član povjerenstva)
Committee memberRozi Andretić Waldowski (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2019-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Dopaminski nagrađujući put je evolucijski očuvana struktura mozga čija je uloga procesuiranje primarnih bioloških nagrada kao što su hrana, reprodukcija, socijalne interakcije te stvaranje percepcije zadovoljstva. Kratkoročna stimulacija psihostimulansima zadržava dopamin u sinaptičkoj pukotini i remeti homeostatske mehanizme što onemogućuje normalnu funkciju dopaminskog sustava. Dugoročna stimulacija potiče dugotrajne promjene na molekularnoj razini uključujući promjene u ekspresiji gena te u... More funkciji i morfologiji neurona. Neuralna plastičnost je proces reorganizacije neurona koji se javlja kao posljedica dugoročne stimulacije dopaminskih receptora. Promjene koje se odvijaju prilikom kronične izloženosti psihostimulansima su smanjena ekspresija D2 dopaminskih receptora i transportera te promjene u biokemijskom sastavu neurona. Takve promjene mogu se pratiti i mjeriti eksperimentalnim metodama poput uvjetovane preferencije mjesta, samoadministracije i bihevioralne senzitizacije. Ulogu u funkcionalnoj plastičnosti imaju transkripcijski faktori CREB (engl. cAMP response element binding protein) i ΔFosB (engl. DeltaFosB) koji posreduju stvaranju tolerancije i senzitizacije vezanih uz povećanu samoadministraciju droge. Smanjenjem transmisije dopamina u NAc (engl. nucleus accumbens) CREB smanjuje senzitizaciju i potiče samoadministraciju droge negativnim potkrepljenjem. Aktivacija ΔFosB povećava senzitizaciju i potiče samoadministraciju droge i primarnih nagrada pozitivnim potkrjepljenjem. Ulogu u morfološkoj plastičnosti imaju neurotrofični faktori kao što je BDNF (engl. brain derived neurotrophic factor), ali i mala nekodirajuća miRNA (engl. micro ribonucleic acid) gdje miRNA-212 utječe na proizvodnju neurotrofičnih faktora i signalizaciju cAMP-a čime indirektno regulira administraciju kokaina. Less
Abstract (english)
The dopamine reward pathway is an evolutionarily conserved brain structure that has a role in processing primary biological rewards such as food, reproduction, social interactions and creating perception of pleasure. Short-term stimulation with psychostimulants retains dopamine in the synaptic cleft and disrupts homeostatic mechanisms, which impairs normal function of the dopamine system. Long-term stimulation promotes longlasting changes at the molecular level, including changes in gene... More expression and neuronal function and morphology. Neural plasticity is a process of neuronal reorganization that occurs as a consequence of a long-term stimulation of dopamine receptors. Changes that occur during chronic exposure to psychostimulants are decreased expression of D2 dopamine receptors and transporters as well as changes in the biochemical composition of neurons. Those changes can be monitored and measured by experimental methods such as conditioned place preference, self-administration and behavioral senzitization. Transcriptional factors CREB (cAMP response element binding protein) and ΔFosB (DeltaFosB) play a role in functional plasticity and mediate tolerance and senzitization related to increased drug self-administration. By reducing dopamine transmission to the NAc (nucleus accumbens), CREB reduces senzitization and promotes drug self-administration by negative reinforcement. Activation of ΔFosB enhances senzitization and promotes self-administration of drugs and primary rewards by postitive reinforcement. Neurotrophic factors, such as BDNF (brain-derived neurotrophic factor), but also small non-coding miRNA (micro ribonucleic acid) play a role in morphological plasticity. miRNA-212 has also been shown to influence the production of neurotrophic factors and signalization of cAMP, that indirectly regulates cocaine administration. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:618985
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2019-11-05 11:28:05
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