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master's thesis
Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihove inhibicijske učinkovitosti na NF-kB i JAK/STAT signalni put
2019. urn:nbn:hr:193:749132
Čubranić, Daria
University of Rijeka
Faculty of Biotechnology and Drug Development

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Čubranić, D. (2019). Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihove inhibicijske učinkovitosti na NF-kB i JAK/STAT signalni put (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:749132

Čubranić, Daria. "Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihove inhibicijske učinkovitosti na NF-kB i JAK/STAT signalni put." Master's thesis, University of Rijeka, 2019. https://urn.nsk.hr/urn:nbn:hr:193:749132

Čubranić, Daria. "Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihove inhibicijske učinkovitosti na NF-kB i JAK/STAT signalni put." Master's thesis, University of Rijeka, 2019. https://urn.nsk.hr/urn:nbn:hr:193:749132

Čubranić, D. (2019). 'Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihove inhibicijske učinkovitosti na NF-kB i JAK/STAT signalni put', Master's thesis, University of Rijeka, accessed 19 November 2024, https://urn.nsk.hr/urn:nbn:hr:193:749132

Čubranić D. Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihove inhibicijske učinkovitosti na NF-kB i JAK/STAT signalni put [Master's thesis]. Rijeka: University of Rijeka; 2019 [cited 2024 November 19] Available at: https://urn.nsk.hr/urn:nbn:hr:193:749132

D. Čubranić, "Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihove inhibicijske učinkovitosti na NF-kB i JAK/STAT signalni put", Master's thesis, University of Rijeka, Rijeka, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:193:749132

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TitleSinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihove inhibicijske učinkovitosti na NF-kB i JAK/STAT signalni put
Title (english)Synthesis of 4,5-dihydrobenzo[b]thieno[2,3-d]oxepine derivatives to test their inhibitory efficiency on NF-kB and JAK/STAT signaling pathways
AuthorDaria Čubranić
MentorKarlo Wittine (mentor)
Committee memberDean Marković (predsjednik povjerenstva)
Committee memberSandra Kraljević Pavelić (član povjerenstva)
Committee memberKarlo Wittine (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2019-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Upala je obrambeni mehanizam, a istovremeno i jedan od glavnih uzroka mnogih bolesti. Na tržištu se trenutno nalazi niz lijekova s protuupalnim djelovanjem, no s obzirom na gastrointestinalne i kardiovaskularne nuspojave povezane s njihovom primjenom, još uvijek smo u potrazi za novim, djelotvornijim lijekovima. U sklopu ovog diplomskog rada pripravljeni su: etil-8-metoksi-4,5-dihidrobenzo[b]tieno[2,3-d]oksepin-2-karboksilat (5) koji je ključni međuprodukt u sintezi te različiti derivati 4,5-dihidrobenzo[b]tieno[2,3-d]oksepina poput amida 6, alkohola 7 i tri različita aminoalkoksi derivata 8a-c. Strukture novopripravljenih spojeva razjašnjene su korištenjem spektroskopije 1H i 13C NMR. Spojevima je namjena ispitati protuupalnu učinkovitost, posebice njihovu sposobnost inhibicije NF-κB i JAK/STAT signalnih puteva.
Abstract (english)
Inflammation is a defense mechanism and at the same time common, causative factor in many diseases. There are currently a number of anti-inflammatory drugs on the market, but they are associated with gastrointestinal and cardiovascular side effects. Therefore, we are still pursuing new molecules, which could serve as effective drugs. As part of this thesis, a key intermediate, ethyl-8-methoxy-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-carboxylate (5) as well as various 4,5-dihydrobenzo[b]thieno[2,3-d]oxepine derivatives such as amide 6, alcohol 7 and three different aminoalkoxy derivatives 8a-c were prepared. The structures of the newly prepared compounds were elucidated on the basis of their 1H and 13C NMR spectra. Anti-inflammatory activity evaluation of the synthesized compounds, especially their ability to inhibit NF-κB and JAK/STAT signaling pathways is planned in the near future.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:749132
Study programmeTitle: Medicinal chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-12-31
Terms of useLicence In copyright icon
Created on2019-09-29 17:05:41