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undergraduate thesis
Inhibitori tirozin kinaza u terapiji raka
2019. urn:nbn:hr:193:081016
Đomlija, Nataly
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Đomlija, N. (2019). Inhibitori tirozin kinaza u terapiji raka (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:081016

Đomlija, Nataly. "Inhibitori tirozin kinaza u terapiji raka." Undergraduate thesis, University of Rijeka, 2019. https://urn.nsk.hr/urn:nbn:hr:193:081016

Đomlija, Nataly. "Inhibitori tirozin kinaza u terapiji raka." Undergraduate thesis, University of Rijeka, 2019. https://urn.nsk.hr/urn:nbn:hr:193:081016

Đomlija, N. (2019). 'Inhibitori tirozin kinaza u terapiji raka', Undergraduate thesis, University of Rijeka, accessed 20 January 2025, https://urn.nsk.hr/urn:nbn:hr:193:081016

Đomlija N. Inhibitori tirozin kinaza u terapiji raka [Undergraduate thesis]. Rijeka: University of Rijeka; 2019 [cited 2025 January 20] Available at: https://urn.nsk.hr/urn:nbn:hr:193:081016

N. Đomlija, "Inhibitori tirozin kinaza u terapiji raka", Undergraduate thesis, University of Rijeka, Rijeka, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:193:081016

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Metadata
TitleInhibitori tirozin kinaza u terapiji raka
Title (english)Tyrosine kinase inhibitors in cancer therapy
AuthorNataly Đomlija
MentorMirela Sedić (mentor)
Committee memberElitza Petkova Markova-Car (predsjednik povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2019-07-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Molecular Biotechnology
Abstract
Tirozin kinaze su vrlo važna skupina enzima koji sudjeluju u procesu prijenosa signala u stanici, reguliraju rast stanica, diferencijaciju apoptozu te niz drugih biokemijskih procesa. Pretjerana ekspresija tirozin kinaza dovodi do poremećaja stanične proliferacije, te je povezana s invazijom tumora, metastazama i angiogenezom. Do danas je istražen veći broj kinaza kao meta u probiru anti-tumorskih lijekova. Inhibitori ovih enzima se natječu sa ATP za ATP vezno mjesto, čime je značajno smanjena fosforilacija tirozin kinaza, što u konačnici rezultirainhibicijom proliferacije stanica raka. Veliki je napredak u liječenju raka postignut upravo primjenom inhibitora tirozin kinaza. U ovome je radu opisana uloga tirozin kinaza u biologiji tumora, zatim navedeni su primjeri klinički odobrenih inhibitora tirozin kinaza u liječenju raka, te su predstavljeni izazovi i ograničenja u razvoju i primjeni inhibitora tirozin kinaza.
Abstract (english)
Tyrosine kinases are very important group of enzymes which regulate signalling pathways in the cell that control, cell growth, differentiation, apoptosis and large number of other biochemical processes. Overexpression of tyrosine kinases leads to abnormal cell proliferation and is associated with tumour invasion, metastasis and angiogenesis. A lot of tyrosine kinases have been used as targets in the screening for anti-tumour drugs. The inhibitors of these enzymes compete with ATP for the ATP-binding site, thereby significantly reducing phosphorylation of tyrosine kinases resulting in inhibition of, cancer cell proliferation. Great progress has been made recently in cancer treatment with tyrosine kinase inhibitors. This thesis describes the role of tyrosine kinases in cancer biology, gives examples of clinically approved, tyrosine kinase inhibitors as anti-cancer drugs and discusses, challenges and limitations of tyrosine kinase inhibitors in cancer treatment.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:081016
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-07-18 11:17:22