prikaz prve stranice dokumenta Matične stanice leđne moždine i molekule koje ih kontroliraju
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undergraduate thesis
Matične stanice leđne moždine i molekule koje ih kontroliraju
2018. urn:nbn:hr:193:713575
Mihalac, Josip
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Mihalac, J. (2018). Matične stanice leđne moždine i molekule koje ih kontroliraju (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:713575

Mihalac, Josip. "Matične stanice leđne moždine i molekule koje ih kontroliraju." Undergraduate thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:713575

Mihalac, Josip. "Matične stanice leđne moždine i molekule koje ih kontroliraju." Undergraduate thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:713575

Mihalac, J. (2018). 'Matične stanice leđne moždine i molekule koje ih kontroliraju', Undergraduate thesis, University of Rijeka, accessed 19 November 2024, https://urn.nsk.hr/urn:nbn:hr:193:713575

Mihalac J. Matične stanice leđne moždine i molekule koje ih kontroliraju [Undergraduate thesis]. Rijeka: University of Rijeka; 2018 [cited 2024 November 19] Available at: https://urn.nsk.hr/urn:nbn:hr:193:713575

J. Mihalac, "Matične stanice leđne moždine i molekule koje ih kontroliraju", Undergraduate thesis, University of Rijeka, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:193:713575

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Metadata
TitleMatične stanice leđne moždine i molekule koje ih kontroliraju
Title (english)Spinal cord stem cells and molecules that control them
AuthorJosip Mihalac
MentorMiranda Mladinić Pejatović (mentor)
Committee memberJelena Ban (predsjednik povjerenstva)
Committee memberMiranda Mladinić Pejatović (član povjerenstva)
Committee memberAntonija Jurak Begonja (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2018-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Ozljede leđne moždine predstavljaju veliki medicinski problem jer trenutno za njih nema efikasne terapije. Prilikom ozljede dolazi do oštećenja motoneurona i prekida u prijenosu živčanih impulsa. Terapeutski potencijal u liječenju ozljeda leđne moždine imaju neuralne matične stanice leđne moždine, kojima posebno obiluje lumbarna regija. Kao najbolji modeli za istraživanje ozljeda leđne moždine pokazali su se glodavci i posebno niži kralježnjaci koji imaju mogućnost potpune regeneracije leđne moždine nakon ozljede. Ependimalne stanice koje okružuju središnji kanal leđne moždine sastoje se od nekoliko podtipova stanica, a pojedini podtipovi posjeduju svojstva matičnih stanica. U istraživanju su analizirane stanice ependimalne i subependimalne regije leđne moždine, njihovi specifični markeri te njihova uloga u fiziološkim i patofiziološkim stanjima. Na primjer, detaljno je opisana izuzetna važnost ovih stanica u stvaranju glijalnog ožiljka nakon ozljede leđne moždine. Također, u radu su opisana i razmotrena istraživanja koja su dokazala da se aktivnost ependimalnih stanica nakon ozljede mijenja ovisno o starosti organizma. Nadalje, opisana su i druga brojna istraživanja koja su usmjerena prema genetičkom reprogramiranju ovih stanica kako bi se povećala njihova proliferacija i diferencijacija u živčane stanice s ciljem pronalaska terapija ne samo za ozljede leđne moždine, već i za druge bolesti poput multiple skleroze ili amiotrofične lateralne skleroze.
Abstract (english)
Spinal cord injury represent a major medical problem because there is currently no effective therapy. In the event of injury there is a loss of motoneuron function and interruption in the transmission of nerve impulses. Therapeutic potential in the treatment of spinal cord injuries have neural stem cells of the spinal cord, particularly abundant in the lumbar region. Rodents and lower vertebrates are the best models for spinal cord injury research because they have the possibility of complete regeneration of the spinal cord after injury. The ependymal cells surrounding the central spinal cord are made up of several cell subtypes, including cells that possess stem cell properties. In this paper, the cells of the ependymal and subependimal spinal cord regions, their specific markers, and their role in physiological and pathophysiological conditions are described in detail. For example, the importance of these cells in the formation of the glial scar after spinal cord injury. Also, the paper describes and analyzes studies that have shown that the activity of ependymal cells after injury changes depending on the age of the organism and other numerous studies aimed the genetic reprogramming of these cells in order to increase their proliferation and differentiation in nerve cells in order to find therapy not only for spinal cord injuries, but also for other diseases such as multiple sclerosis or amyotrophic lateral sclerosis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:713575
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-11-06 07:28:15