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undergraduate thesis
Biološki učinak makrolidnih konjugata
2018. urn:nbn:hr:193:526319
Smolčić, Mislav
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Smolčić, M. (2018). Biološki učinak makrolidnih konjugata (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:526319

Smolčić, Mislav. "Biološki učinak makrolidnih konjugata." Undergraduate thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:526319

Smolčić, Mislav. "Biološki učinak makrolidnih konjugata." Undergraduate thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:526319

Smolčić, M. (2018). 'Biološki učinak makrolidnih konjugata', Undergraduate thesis, University of Rijeka, accessed 02 January 2025, https://urn.nsk.hr/urn:nbn:hr:193:526319

Smolčić M. Biološki učinak makrolidnih konjugata [Undergraduate thesis]. Rijeka: University of Rijeka; 2018 [cited 2025 January 02] Available at: https://urn.nsk.hr/urn:nbn:hr:193:526319

M. Smolčić, "Biološki učinak makrolidnih konjugata", Undergraduate thesis, University of Rijeka, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:193:526319

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Metadata
TitleBiološki učinak makrolidnih konjugata
AuthorMislav Smolčić
MentorRoberto Antolović (mentor)
MentorKarlo Wittine (mentor)
Committee memberNela Malatesti (predsjednik povjerenstva)
Committee memberElitza Petkova Markova - Car (član povjerenstva)
Committee memberKarlo Wittine (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2018-09-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Antimikrobno djelovanje makrolida prepoznato je u 20.-tom stoljeću kada su se počeli primjenjivati u liječenju infekcija uzrokovanih bakterijama i gljivicama, a također i liječenju raka. Prvi 15-člani makrolid koji je pokazao terapijske učinke bio je azitromicin. Od postavljanja azitromicina na tržište do danas, otkriven je veliki broj drugih makrolida i makrolidnih struktura različitog spektra djelovanja. No, zbog kontinuiranog korištenja makrolida i nepravilne primjene pojavio se problem rezistentnosti mikroorganizama i na tu grupu antimikrobnih spojeva. Kako bi se riješio taj problem započeta su istraživanja makrolidnih konjugata, odnosno derivata makrolida s ciljem kombiniranja povoljnih karakteristika makrolida uvođenjem dodatnih kemijskih skupina poput esterske, amidne, ureidne, karbamatne, sulfonamidne i dr. Makrolid se također može modificirati na način da se s kinolonom spaja u jedinstvenu cjelinu povezivanjem premosnicom određene duljine. Takav spoj se zove makrolon i pokazao se vrlo uspješnim u liječenju bakterijskih infekcija. Danas se u literaturi može pronaći veliki broj makrolidnih konjugata specifične aktivnosti u određenom terapijskom području, koje nismo zbog opsežnosti materije obuhvatili ovim radom. Cilj je ovog rada obuhvatiti biološki najučinkovitije makrolidne konjugate s antibakterijskim, protutumorskim i antivirusnim učinkom.
Abstract (english)
Antimicrobial effect of macrolides has been recognized in the 20th century when they were used for treatment of infections caused by bacteria and fungi, as well as cancer. Azithromycin was the first fifteen-membered macrolide that showed therapeutic effect. Since placement of azithromycin on market, a large number of other macrolides and macrolide structures with different biological effects was discovered. However, continuous and inadequate usage of macrolides has resulted in antibiotic resistance of microorganisms, even for new generations of antimicrobial compounds. With the aim of addressing that issue, research of macrolide conjugates or macrolide derivates was initiated. The research was steered to combine beneficial macrolide characteristics with additional chemical groups such as ester, amide, ureido, carbamate, sulfonamide, and others. Macrolide can also be modified by attaching quinolone via a linker of specific length. Such compound is named macrolone and it has been proven to be effective for treatment of bacterial infections. Although a large number of macrolide conjugates with specific activities can be found in the literature not all were mentioned within this paper because of the immensity of the data. The main aim was to present only biologically most effective macrolide conjugates with antibacterial, antitumor or antiviral activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:526319
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-10-31 12:11:44