prikaz prve stranice dokumenta BIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA
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undergraduate thesis
BIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA
2018. urn:nbn:hr:193:734807
Sučić, Martina
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Sučić, M. (2018). BIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:734807

Sučić, Martina. "BIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA." Undergraduate thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:734807

Sučić, Martina. "BIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA." Undergraduate thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:734807

Sučić, M. (2018). 'BIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA', Undergraduate thesis, University of Rijeka, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:193:734807

Sučić M. BIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA [Undergraduate thesis]. Rijeka: University of Rijeka; 2018 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:193:734807

M. Sučić, "BIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA", Undergraduate thesis, University of Rijeka, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:193:734807

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Metadata
TitleBIOLOGIJA FIBROBLASTA U MIKROOKOLIŠU TUMORA
AuthorMartina Sučić
MentorIvana Ratkaj (mentor)
Committee memberMiranda Mladinić Pejatović (predsjednik povjerenstva)
Committee memberIvana Ratkaj (član povjerenstva)
Committee memberMirela Sedić (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2018, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Tumorski mikrookoliš (TME) se sastoji od staničnih i nestaničnih komponenata te je važan za razvoj i metastaziranje karcinoma. Fibroblasti povezani s tumorom (CAF-ovi) su jedne od najvažnijih staničnih komponenata TME-a, koje imaju iznimnu važnost u nastanku, progresiji, invaziji i metastaziranju stanica karcinoma putem različitih mehanizama. CAF-ovi su heterogena populacija stanica, koje imaju različito podrijetlo te zbog toga i višestruke pozitivne markere. Također, imaju i širok spektar funkcija kojima promiču tumore, od parakrine signalizacije putem različitih faktora rasta, citokina i kemokina, remodeliranja i degradacije izvanstaničnog matriksa, do promicanja invazije, angiogeneze i metastaziranja. U ovom radu su sažeta saznanja iz pregleda literature koja su vezana za tumorski mikrookoliš i CAF-ove, njihovom podrijetlu i ulogama u tumorigenezi i metastaziranju.
Abstract (english)
Tumor microenvironment (TME) consists of cellular and non-cellular components and as such is important for the development and invasion of cancer. Cancer-associated fibroblasts (CAFs) are one of the most important cellular components of TME, which have play extremely important role in the formation, progression, invasion and metastasis of carcinoma cells by various mechanisms. CAFs are heterogeneous cell population, which can originate from different sources and have multiple positive markers. Also, they have a wide range of functions to promote tumors, from paracrine signalling by different growth factors, cytokines and chemokines, remodelling and degradation of extracellular matrix, to the promotion of invasion, angiogenesis and metastasis. This paper summarizes findings from literature which are related to tumor microenvironment and CAFs, their origin and roles in tumorigenesis and metastasis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:734807
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-10-26 07:42:25