prikaz prve stranice dokumenta Razvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida
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master's thesis
Razvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida
2016. urn:nbn:hr:193:230209
Lovreković, Vanda
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Lovreković, V. (2016). Razvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:230209

Lovreković, Vanda. "Razvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida." Master's thesis, University of Rijeka, 2016. https://urn.nsk.hr/urn:nbn:hr:193:230209

Lovreković, Vanda. "Razvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida." Master's thesis, University of Rijeka, 2016. https://urn.nsk.hr/urn:nbn:hr:193:230209

Lovreković, V. (2016). 'Razvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida', Master's thesis, University of Rijeka, accessed 16 November 2024, https://urn.nsk.hr/urn:nbn:hr:193:230209

Lovreković V. Razvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida [Master's thesis]. Rijeka: University of Rijeka; 2016 [cited 2024 November 16] Available at: https://urn.nsk.hr/urn:nbn:hr:193:230209

V. Lovreković, "Razvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida", Master's thesis, University of Rijeka, Rijeka, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:193:230209

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Metadata
TitleRazvoj sintetskog postupka gvanilacije upotrebom bis(trimetilsilil)karbodiimida
Title (english)Development of synthetic procedure for guanylation employing bis(trimethylsilyl)carbodiimide
AuthorVanda Lovreković
MentorDavor Margetić (mentor)
Committee memberDavor Margetić (predsjednik povjerenstva)
Committee memberSandra Kraljević Pavelić (član povjerenstva)
Committee memberKarlo Wittine (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2016-10-06, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Pokušan je razvoj nove sintetske metode za pripravu monosupstituiranih gvanidina reakcijom amina sa bis-TMS karbodiimidom. Metoda nije uspjela radi slabe reaktivnosti korištenog karbodiimida. Primjenom literaturno opisanog reagensa za gvanilaciju, efikasno je pripravljen gvanidin/klorin-e6 131-diaminoetilkarboksamid konjugat i potpuno karakteriziran 1H NMR spektroskopijom. Osim alifatskih amina, za pripravu gvanidin/porfirin konjugata sintetiziran je tetrafenil porfirin, koji je selektivno nitriran, te zatim reduciran u odgovarajući amin. Mala količina dostupnog aminoporfirina dozvolila je samo inicijalno testiranje slijedećeg reakcijskog koraka, priprave 4-benzoiltioureje-TPP konjugata.
Abstract (english)
Development of new synthetic methods for preparing mono-substituted guanidines by reaction of amines with bis-TMS carbodiimide was attempted. The method failed due to poor reactivity of used carbodiimide. Using the literature described guanylation reagent, guanidine/chlorin e6-131-conjugate diaminoethylcarboxamide was prepared effectively and fully characterized by 1H NMR spectroscopy. In addition to aliphatic amines, for the preparation of guanidine/porphyrin conjugates tetraphenyl porphyrin was synthesized, which was selectively nitrated and then reduced to the corresponding amine. A small amount of available aminoporphyrin allowed only initial testing of the next reaction step in preparation of 4-benzoylthiourea-TPP conjugate.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:230209
Study programmeTitle: Medicinal chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resourceText
File originBorn digital
Access conditionsClosed access
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Created on2016-10-31 13:57:12