Title Najnovija dostignuća stanične imunoterapije
Title (english) The latest achievements in cellular immunotherapy
Author Noa Keš
Mentor Miranda Mladinić Pejatović (mentor)
Committee member Miranda Mladinić Pejatović (član povjerenstva)
Committee member Nela Malatesti (predsjednik povjerenstva)
Committee member Stribor Marković (član povjerenstva)
Granter University of Rijeka (Faculty of Biotechnology and Drug Development) Rijeka
Defense date and country 2024-07-09, Croatia
Scientific / art field, discipline and subdiscipline BIOTECHNICAL SCIENCES Biotechnology
Abstract Zbog toga što rak predstavlja jedan od vodećih uzroka smrti u svijetu, intenzivno se radi na otkriću novih vrsta terapije. Upravo imunoterapija predstavlja nov i moderan pristup u liječenju raka, zaraznih bolesti i autoimunih bolesti. Obećavajuće rezultate pokazuje osobito u liječenju malignih formacija. Za razliku od tradicionalni terapija (kemoterapija i radioterapija), ona direktnim djelovanjem na imunosni sustav postiže efikasnu reakciju i odgovor na tumore, što je čini sigurnijom i manje štetnom za pacijente. Dijeli se na nekoliko značajnih područja, staničnu imunoterapiju, imunoterapiju antitijelima, checkpoint inhibitore, citokinsku terapiju, imunomodulatore i cjepiva. Zbog svojih iznimnih rezultata u kliničkim ispitivanjima pa i činjenice da je već nekoliko terapija odobreno od strane FDA, odlučio sam više pažnje posvetiti upravo staničnoj imunoterapiji, a posebice CAR-T stanicama. Stanična imunoterapija doživjela je veliki procvat te čini temelj za budućnost liječenja raka. Ona se bazira na poboljšanju funkcija imunosnih stanica njihovom modifikacijom, multiplikacijom i aktivacijom, a dijeli se prema vrsti stanice čije se funkcija poboljšava. Razlikujemo adoptivnu T staničnu (TILs, CAR-T, TCR-T), NK staničnu, CIK staničnu imunoterapiju i DC cjepiva. Najznačajnija vrsta terapije, upravo je adoptivna T stanična imunoterapija. Pokazuje iznimno dobre rezultate u liječenju raka, a zbog intenzivnog i predanog istraživanja u ovom području rada, već je odobren niz terapija ove vrste.
Abstract (english) Because cancer is one of the leading causes of death worldwide, intensive efforts are being made to discover new types of therapy. Immunotherapy represents a new and modern approach in the treatment of cancer, infectious diseases, and autoimmune diseases. It shows promising results especially in the treatment of malignant formations. Unlike traditional therapies (chemotherapy and radiotherapy), it achieves an effective reaction and response to tumors by directly acting on the immune system, making it safer and less harmful to patients. It is divided into several significant areas: cellular immunotherapy, antibody immunotherapy, checkpoint inhibitors, cytokine therapy, immunomodulators, and vaccines. Due to its remarkable results in clinical trials and the fact that several therapies have already been approved by the FDA, I have decided to focus more on cellular immunotherapy, especially on CAR-T cells. Cellular immunotherapy has experienced a significant breakthrough and forms the foundation for the future cancer treatments. It is based on enhancing the functions of immune cells through their modification, multiplication, and activation, and it is categorized based on the type of cell whose function is being improved. We distinguish between adoptive T cell (TILs, CAR-T, TCR-T), NK cell, CIK cell immunotherapy, and DC vaccines. The most significant type of therapy is adoptive T cell immunotherapy. It shows exceptionally good results in cancer treatment, and due to intensive and dedicated work, a series of therapies of this kind have already been approved.
Keywords
imunoterapija
rak
T-stanična imunoterapija
NK stanična imunoterapija
DC cjepiva
Keywords (english)
immunotherapy
cancer
T-cell immunotherapy
NK-cell immunotherapy
DC vaccines
Language croatian
URN:NBN urn:nbn:hr:193:839066
Study programme Title: Biotechnology and drug research Study programme type: university Study level: undergraduate Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biotehnologije i istraživanja lijekova)
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Created on 2024-07-12 21:01:07