prikaz prve stranice dokumenta The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1
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Scientific paper - review paper
The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1
Communicative and Integrative Biology, 10 (2017), 4; 4. https://doi.org/10.1080/19420889.2017.1335375
Bradshaw, Nicholas J.

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Bradshaw, N. J. (2017). The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1. Communicative and Integrative Biology, 10. (4), e1335375. doi: 10.1080/19420889.2017.1335375

Bradshaw, Nicholas J.. "The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1." Communicative and Integrative Biology, vol. 10, no. 4, 2017, pp. e1335375. https://doi.org/10.1080/19420889.2017.1335375

Bradshaw, Nicholas J.. "The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1." Communicative and Integrative Biology 10, no. 4 (2017): e1335375. https://doi.org/10.1080/19420889.2017.1335375

Bradshaw, N. J. (2017) 'The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1', Communicative and Integrative Biology, 10(4), pp. e1335375. doi: 10.1080/19420889.2017.1335375

Bradshaw NJ. The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1. Communicative and Integrative Biology [Internet]. 2017 June 02 [cited 2024 April 25];10(4):e1335375. doi: 10.1080/19420889.2017.1335375

N. J. Bradshaw, "The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1", Communicative and Integrative Biology, vol. 10, no. 4, pp. e1335375, June 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:950901. [Accessed: 25 April 2024]

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Metadata
Title (english)The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1
AuthorNicholas J. Bradshaw
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Biology
Abstract (english)
DISC1 and NDEL1 are both key proteins in cortical neurodevelopment, which are each also implicated in the pathogenesis of mental illness. That the two proteins interact with each other in a functionally important manner is well established, but two distinct binding domains for NDEL1 on DISC1 have been proposed. A partial domain structure for DISC1 has recently been described, consisting of 4 structured regions referred to as “D,” “I,” “S” and “C” respectively, with one of the NDEL1 binding sites lying in the “C” region of DISC1. In light of this domain structure, it can be deduced that this site is the likely location at which NDEL1 binds, although the other proposed site (which lies in the DISC1 “I” and “S” regions) may indirectly impact on DISC1-NDEL1 interactions through determination of the oligomeric state of DISC1.
Keywords (english)
Languageenglish
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCommunicative and Integrative Biology
Numberingvol. 10, no. 4, p. e1335375, 4
BPC0 CHF
p-ISSN1942-0889
DOIhttps://doi.org/10.1080/19420889.2017.1335375
URN:NBNurn:nbn:hr:193:950901
Publication2017-06-02
Document URLhttps://www.tandfonline.com/doi/full/10.1080/19420889.2017.1335375
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-09-14 11:14:48